Factors Influencing the Clearance Rates of Colloidal Particles from the Rabbit Knee Joint
Factors Influencing the Clearance Rates of Colloidal Particles from the Rabbit Knee Joint
复制标题
影响兔膝关节胶体颗粒清除率的因素
DOI：
10.1007/978-94-011-9728-1_17
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
R. Chawla
中科院分区：
文献类型：
--
作者：
I. Kellaway;R. Chawla
抗炎剂通常直接注射到类风湿关节中，以尽量减少副作用并将药物定位在关节内，或更具体地定位在参与分解代谢病变的那些细胞内。研究表明，关节内注射皮质类固醇在临床上可用于局部姑息治疗（Hollander 1972）。在类风湿性关节炎中，它可能会抑制受累最严重的关节的活动，直到其他药物方案的治疗效果确立为止。进一步的研究表明，需要相对高剂量的类固醇才能暂时改善症状，并且有证据表明药物在 24 小时内从关节间隙中渗出（Goetzl 等人，1974 年）。储库疗法可以使用微晶药物悬浮液来实现，尽管溶酶体药物应该提供更有效的药物递送系统。
Anti-inflammatory agents are often injected directly into rheumatoid joints in order to minimise side-effects and to localise drugs within the joints, or more specifically within those cells involved in the catabolic lesions. It has been shown that intra-articular corticosteroid is clinically useful for local palliative therapy (Hollander 1972). In rheumatoid arthritis it may suppress activity in the most severely involved joints until the therapeutic effects of other drug regimes have been established. Further studies showed that relatively high doses of steroid were required to produce transient amelioration of the symptoms, and there was evidence of drug leaching from the joint space within 24 hours (Goetzl et al. 1974). Depot therapy can be achieved using a microcrystalline drug suspension, although lysosomotropic agents should provide an even more efficient drug delivery system.