Tests for Anxiety-Related Behavior in Mice.
Tests for Anxiety-Related Behavior in Mice.
复制标题
DOI：
10.1002/9780470942390.mo150010
复制
发表时间：
2015-12-02
影响因子：
--
通讯作者：
Wurst, Wolfgang
中科院分区：
文献类型：
--
作者：
Holter, Sabine M;Einicke, Jan;Wurst, Wolfgang
近亲交配小鼠品系和转基因小鼠模型与神经精神疾病相关特征的表型包括评估它们与焦虑相关的行为。已经开发了各种测试来测量实验室啮齿动物的焦虑，这些测试多年来一直受到关于其有效性的审查。在这里，我们描述了在老鼠身上使用最广泛的焦虑测试。我们提出的方案是在德国小鼠诊所(GMC)使用的既定方法，通过这些方法，可以成功地在小鼠突变中发现焦虑的变化。此外，由于小鼠的基线焦虑水平很容易受到各种干扰的影响，我们仔细概述了需要考虑的关键参数。
Phenotyping of inbred mouse strains and genetically modified mouse models for characteristics related to neuropsychiatric diseases includes assessing their anxiety-related behavior. A variety of tests have been developed to measure anxiety in laboratory rodents and these tests have been placed under scrutiny over the years concerning their validity. Here we describe the most widely used tests for anxiety in mice. The protocols we present are established methods used in the German Mouse Clinic (GMC), with which alterations in anxiety could successfully be discovered in mouse mutants. Moreover, since baseline anxiety levels in mice are easily influenced by a great variety of disturbances, we carefully outline the critical parameters that need to be considered.