Regulation of the meiotic divisions of mammalian oocytes and eggs.
Regulation of the meiotic divisions of mammalian oocytes and eggs.
复制标题
DOI：
10.1042/bst20170493
复制
发表时间：
2018-08-20
影响因子：
3.9
通讯作者：
Jones KT
中科院分区：
文献类型：
--
作者：
Sanders JR;Jones KT
哺乳动物的卵母细胞由促黄体激素启动，由精子完成两次减数分裂。第一次分裂发生在成熟的Graafian卵泡中，在排卵前的几个小时内，并在极端不对称的细胞分裂和两对同源染色体的分离中达到高潮。新产生的成熟卵在排卵前的第二次减数分裂中期重新开始，并且仅在配子融合时由精子启动的Ca2+信号之后完成减数分裂。在这里，我们审查的细胞事件，管理通过的卵母细胞减数分裂I的纺锤体组装检查点在调节其时间的作用为重点。在减数分裂II中，我们研究了卵子如何实现其逮捕和受精Ca2+信号如何允许胚胎发育的启动。
Initiated by luteinizing hormone and finalized by the fertilizing sperm, the mammalian oocyte completes its two meiotic divisions. The first division occurs in the mature Graafian follicle during the hours preceding ovulation and culminates in an extreme asymmetric cell division and the segregation of the two pairs of homologous chromosomes. The newly created mature egg rearrests at metaphase of the second meiotic division prior to ovulation and only completes meiosis following a Ca2+ signal initiated by the sperm at gamete fusion. Here, we review the cellular events that govern the passage of the oocyte through meiosis I with a focus on the role of the spindle assembly checkpoint in regulating its timing. In meiosis II, we examine how the egg achieves its arrest and how the fertilization Ca2+ signal allows the initiation of embryo development.