The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol.
The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol.
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DOI：
10.1161/strokeaha.113.002332
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发表时间：
2013-10
期刊：
影响因子：
8.3
通讯作者：
Langefeld CD
中科院分区：
文献类型：
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作者：
Woo D;Rosand J;Kidwell C;McCauley JL;Osborne J;Brown MW;West SE;Rademacher EW;Waddy S;Roberts JN;Koch S;Gonzales NR;Sung G;Kittner SJ;Birnbaum L;Frankel M;Testai FD;Hall CE;Elkind MS;Flaherty M;Coull B;Chong JY;Warwick T;Malkoff M;James ML;Ali LK;Worrall BB;Jones F;Watson T;Leonard A;Martinez R;Sacco RI;Langefeld CD
脑出血（ICH）的流行病学研究一致表明，在非西班牙裔白人、黑人和西班牙裔人群中，脑出血的发病率、部位、发病年龄和结局存在差异。我们在此报告这项大型、前瞻性、多中心病例对照研究的设计和方法。ERICH研究是一项针对ICH的多中心、前瞻性病例对照研究。病例通过热追踪识别，并使用标准表型和危险因素信息登记，包括神经影像学和血液样本采集。对照通过随机数字拨号集中识别，以按年龄（+/ - 5岁）、种族、民族、性别和大都市地区匹配病例。截至2013年3月22日，研究招募了1655例脑出血患者，占该日期目标的101.5%；招募了851名对照，占该日期目标的67.2%（1267名对照），共招募了2506名受试者，占该日期目标（2897名受试者）的86.5%。在入组的1655例病例中，1640例病例访谈被录入数据库，其中非西班牙裔黑人628例（38%），非西班牙裔白人458例（28%），西班牙裔554例（34%）。在提交的1197例影像学中，876例（73.2%）有24小时随访CT，除CT影像学外，607例有MRI评估。ERICH研究是一项针对脑出血的大型病例对照研究，特别强调招募少数民族人群，以确定脑出血的遗传和流行病学危险因素以及脑出血后的结果。
Epidemiologic studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. The ERICH study is a multi-center, prospective case-control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (+/−5 years), race, ethnicity, gender and metropolitan region. As of March 22, 2013, 1,655 cases of ICH had been recruited into the study which is 101.5% of the target for that date and 851 controls had been recruited which is 67.2% of the target for that date (1,267 controls) for a total of 2,506 subjects which is 86.5% of the target for that date (2,897 subjects). Of the 1,655 cases enrolled, 1,640 cases had the case interview entered into the database of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white and 554 (34%) were Hispanic. Of the 1,197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available In addition to CT imaging, 607 cases have had MRI evaluation. The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiologic risk factors for ICH and outcomes after ICH.