Changes in the adenylate energy charge in human blood platelets induced by adenosine diphosphate.
Changes in the adenylate energy charge in human blood platelets induced by adenosine diphosphate.
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二磷酸腺苷引起的人血小板中腺苷酸能量电荷的变化。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
D. Mills
中科院分区：
文献类型：
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作者：
D. Mills
当 37°C 富含血小板的血浆暴露于低浓度的二磷酸腺苷 (ADP) 时，血小板的形状会从扁平的圆盘变成不规则的球体1，如果搅拌混合物并提供包括钙离子和纤维蛋白原在内的必要辅助因子，则会发生聚集。这种对 ADP 反应的详细机制是许多推测性假设 2-5 的主题。在这里，我报告了外源 ADP 对血小板腺嘌呤核苷酸代谢影响的观察结果，这可能与诱导血小板聚集有关。
WHEN platelet rich plasma at 37° C is exposed to low concentrations of adenosine diphosphate (ADP) the platelets change in shape from flat disks to irregular spheres1 and if the mixture is stirred and provided that necessary cofactors including calcium ions and fibrinogen are present, aggregation then takes place. The detailed mechanism of this response to ADP is the subject of a number of speculative hypotheses2–5. Here I report an observation on the effects of exogenous ADP on platelet adenine nucleotide metabolism that may be relevant to the induction of platelet aggregation.