Extended Frontal Networks for Visual and Auditory Working Memory
Extended Frontal Networks for Visual and Auditory Working Memory
复制标题
视觉和听觉工作记忆的扩展额叶网络
DOI：
10.1093/cercor/bhab249
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Somers, David C
中科院分区：
文献类型：
--
作者：
Noyce, Abigail L;Lefco, Ray W;Brissenden, James A;Tobyne, Sean M;Shinn-Cunningham, Barbara G;Somers, David C
工作记忆（WM）支持短暂感觉信息的持久表征。视觉和听觉刺激对WM产生不同的要求，并调动不同的脑网络。单独的听觉和视觉偏倚的WM网络延伸到额叶，但试图分割人类额叶皮层面临着一些挑战，包括细粒度组织和受试者之间的可变性。在这里，我们使用来自两个视觉偏倚和两个听觉偏倚额叶结构的差异内在功能连接来识别额叶皮层中额外的候选感觉偏倚区域。然后，我们检查了任务功能磁共振成像在视觉和听觉2-back WM期间的直接对比，以验证这些候选区域。个体受试者额叶中有3个视觉偏倚区域和5个听觉偏倚区域被双侧激活（N= 14,7名女性）。这些区域在被动暴露于任务刺激时表现出感官偏好，这种偏好在WM期间更强。对新发现的和先前发现的双侧感觉偏倚区域内在连通性的层次聚类分析证实，它们在功能上分离为视觉和听觉网络，尽管这些网络在解剖学上是交叉的。我们还观察到额颞叶听觉WM网络具有高度选择性，并且与服务于非WM功能的结构具有很强的功能连通性，而额顶叶视觉WM网络在层次上与多需求认知系统相融合。
Working memory (WM) supports the persistent representation of transient sensory information. Visual and auditory stimuli place different demands on WM and recruit different brain networks. Separate auditory- and visual-biased WM networks extend into the frontal lobes, but several challenges confront attempts to parcellate human frontal cortex, including fine-grained organization and between-subject variability. Here, we use differential intrinsic functional connectivity from 2 visual-biased and 2 auditory-biased frontal structures to identify additional candidate sensory-biased regions in frontal cortex. We then examine direct contrasts of task functional magnetic resonance imaging during visual versus auditory 2-back WM to validate those candidate regions. Three visual-biased and 5 auditory-biased regions are robustly activated bilaterally in the frontal lobes of individual subjects (N= 14, 7 women). These regions exhibit a sensory preference during passive exposure to task stimuli, and that preference is stronger during WM. Hierarchical clustering analysis of intrinsic connectivity among novel and previously identified bilateral sensory-biased regions confirms that they functionally segregate into visual and auditory networks, even though the networks are anatomically interdigitated. We also observe that the frontotemporal auditory WM network is highly selective and exhibits strong functional connectivity to structures serving non-WM functions, while the frontoparietal visual WM network hierarchically merges into the multiple-demand cognitive system.