Demarcation of secondary hyperalgesia zones: Punctate stimulation pressure matters.
Demarcation of secondary hyperalgesia zones: Punctate stimulation pressure matters.
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继发性痛觉过敏区的划分：点状刺激压力很重要。
DOI：
10.1016/j.jneumeth.2015.08.018
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发表时间：
2015
影响因子：
3
通讯作者：
Werner,MadsU
中科院分区：
文献类型：
--
作者：
Ringsted,ThomasK;Enghuus,Casper;Petersen,MortenA;Werner,MadsU
背景继发性痛觉过敏是指损伤部位附近正常组织痛觉敏感性的增加，是反映损伤对中枢神经系统影响的中枢敏感性指标。继发性痛觉过敏区（SHA），通常由聚酰胺单丝评估，是人类镇痛药物作用研究的重要结果。然而，由于在划定的继发性痛觉过敏区的方法似乎不一致的跨研究，我们研究了一个标准化的方法后，SHA的测量一级烧伤injury（BI）.New methodThe study is a two-observer，test-retest study with the two session separated by 6 wk.采用了调整后的双盲设计，以检查SHA的日间和个体间变异性。在23名健康志愿者（12名女性/11名男性）中，通过接触式热电极（47.0 °C，420 s，2.5 × 5.0 cm 2）诱导BI。SHA，划定由聚酰胺单丝（弯曲力：0.2，69和2569 mN）和一个“加权针”刺激器（512 mN），进行了评估后45至75分钟，每个BIS.ResultsA随机效应，线性混合模型表现出引发的皮肤压力（mN/mm 2）和SHA之间的对数相关性（P< 0.0001）。未观察到SHA的日间或个体间差异。组内相关系数，在0.51至0.84的范围内，表明一个温和的，几乎完美的可靠性之间的observers.Comparison与现有的methodsNo标准化的方法在SHA评估迄今为止一直presented.ConclusionsThis是第一个研究表明，划定二级痛觉过敏区取决于所使用的点状刺激器的开发压力。
BackgroundSecondary hyperalgesia is increased sensitivity in normal tissue near an injury, and it is a measure of central sensitization reflecting injury-related effects on the CNS. Secondary hyperalgesia areas (SHAs), usually assessed by polyamide monofilaments, are important outcomes in studies of analgesic drug effects in humans. However, since the methods applied in demarcating the secondary hyperalgesia zone seem inconsistent across studies, we examined the effect of a standardized approach upon the measurement of SHA following a first degree burn injury (BI).New methodThe study was a two-observer, test–retest study with the two sessions separated by 6 wk. An observer-blinded design adjusted to examine day-to-day and observer-to-observer variability in SHA was used. In 23 healthy volunteers (12 females/11 males) a BI was induced by a contact thermode (47.0 °C, 420 s, 2.5 × 5.0 cm2). The SHA, demarcated by polyamide monofilaments (bending force: 0.2, 69 and 2569 mN) and a “weighted-pin” stimulator (512 mN), were assessed 45 to 75 min after each BI.ResultsA random effect, linear mixed model demonstrated a logarithmic correlation between elicited skin pressures (mN/mm2) and the SHAs (P< 0.0001). No day-to-day or observer-to-observer differences in SHAs were observed. Intraclass correlation coefficients, in the range of 0.51 to 0.84, indicated a moderate to almost perfect reliability between observers.Comparison with existing methodsNo standardized approach in SHA-assessment has hitherto been presented.ConclusionsThis is the first study to demonstrate that demarcation of secondary hyperalgesia zones depends on the developed pressure of the punctate stimulator used.