Biomechanical response of human spleen in tensile loading
Biomechanical response of human spleen in tensile loading
复制标题
DOI：
10.1016/j.jbiomech.2011.10.022
复制
发表时间：
2012-01-10
影响因子：
2.4
通讯作者：
Duma, Stefan M.
中科院分区：
文献类型：
--
作者：
Kemper, Andrew R.;Santago, Anthony C.;Duma, Stefan M.
钝性脾损伤最常由机动车碰撞引起，并且与高死亡率相关。为了使用有限元模型等工具准确评估汽车相关脾脏损伤的风险，必须根据适当的生物力学数据开发和验证组织水平公差值和合适的材料模型。本研究共对脾实质试样进行了41次拉伸试验，对脾包膜/实质试样进行了29次拉伸试验。从新鲜人脾中获得标准狗骨试样，并在死亡后48小时内进行测试。每个试样在四种加载速率之一下进行一次失效测试，以研究速率依赖性的影响。在每个样本夹具处获得载荷和加速度数据。放置在标本上的高速视频和光学标记用于测量局部位移。在试样标距长度的失效位置处计算失效应力和应变。研究结果表明，脾实质和包膜都是速率依赖性的，较高的加载速率产生较高的破坏应力和较低的破坏应变。结果还表明，脾被膜的破坏应力明显大于下面的实质。总之，本研究提供了新的生物力学数据，证明了人类脾脏组织在拉伸载荷下的速率依赖性组织水平耐受值，这有助于改进用于评估钝性创伤中损伤风险的有限元模型。由爱思唯尔有限公司发布
Blunt splenic injuries are most frequently caused as a result of motor vehicle collisions and are associated with high mortality rates. In order to accurately assess the risk of automotive related spleen injuries using tools such as finite element models, tissue level tolerance values and suitable material models must be developed and validated based on appropriate biomechanical data. This study presents a total of 41 tension tests performed on spleen parenchyma coupons and 29 tension tests performed on spleen capsule/parenchyma coupons. Standard dog-bone coupons were obtained from fresh human spleen and tested within 48 h of death. Each coupon was tested once to failure at one of the four loading rates to investigate the effects of rate dependence. Load and acceleration data were obtained at each of the specimen grips. High-speed video and optical markers placed on the specimens were used to measure local displacement. Failure stress and strain were calculated at the location of failure in the gage length of the coupon. The results of the study showed that both the spleen parenchyma and the capsule are rate dependent, with higher loading rates yielding higher failure stresses and lower failure strains. The results also show that the failure stress of the splenic capsule is significantly greater than that of the underlying parenchyma. Overall, this study provides novel biomechanical data that demonstrate the rate dependent tissue level tolerance values of human spleen tissue in tensile loading, which can aid in the improvement of finite element models used to assess injury risk in blunt trauma. Published by Elsevier Ltd.