Electrical Stimulation of the Infraorbital Nerve Induces Diving Reflex in a Dose-Controlled Manner.
Electrical Stimulation of the Infraorbital Nerve Induces Diving Reflex in a Dose-Controlled Manner.
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眶下神经的电刺激以剂量控制的方式诱导潜水反射。
DOI：
10.1109/embc44109.2020.9176845
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Li,Chunyan
中科院分区：
文献类型：
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作者：
Shah,KevinA;Sonti,AnupN;Wu,Yi-Chen;Powell,Keren;Doobay,Mohini;Narayan,RajK;Li,Chunyan
“潜水反射”（DR）是一种非常强大的自主神经反射，有助于在缺氧/缺氧条件下生存，并可通过调节心血管、呼吸和神经系统引发多方面的生理效应，用于治疗各种疾病。DR可以由施加到前鼻粘膜和鼻旁区域的冷水或有毒气体诱导，其可以刺激三叉神经热或化学受体以将传入信号发送到介导交感神经和副交感神经系统的髓核。尽管这些方法很有前途，但由于无法精确控制疗效-反应关系、缺乏重现性以及难以在临床环境中实施，因此尚未在常规临床实践中采用。在这项研究中，我们提出了电三叉神经（眶）神经刺激（eTINS）的能力，以剂量可控的方式诱导DR。我们发现，eTINS不仅触发与在动物/人中观察到的“经典”DR模式相容的特定生理变化，而且还在不同水平上控制诱导的DR。这项研究首次表明，DR的强度可通过剂量控制，并有可能在控制良好的研究环境中研究其对各种病理的保护机制。
The "diving reflex" (DR) is a very powerful autonomic reflex that facilitates survival in hypoxic/anoxic conditions and could trigger multifaceted physiologic effects for the treatment of various diseases by modulating the cardiovascular, respiratory, and nervous systems. The DR can be induced by cold water or noxious gases applied to the anterior nasal mucosa and paranasal regions, which can stimulate trigeminal thermo- or chemo-receptors to send afferent signals to medullary nuclei which mediate the sympathetic and parasympathetic nervous systems. Although promising, these approaches have yet to be adopted in routine clinical practice due to the inability to precisely control exposure-response relationships, lack of reproducibility, and difficulty implementing in a clinical setting. In this study, we present the ability of electrical Trigeminal (Infraorbital) Nerve Stimulation (eTINS) to induce the DR in a dose-controllable manner. We found that eTINS not only triggered specific physiological changes compatible with the pattern of "classic" DR observed in animals/humans, but also controlled the induced-DR at varying levels. This study demonstrates, for the first time, that the intensity of the DR is controllable by dose and opens possibility to investigate its protective mechanism against various pathologies in well-controlled research settings.