GADOLINIUM-LABELED LIPOSOMES - TARGETED MR CONTRAST AGENTS FOR THE LIVER AND SPLEEN
GADOLINIUM-LABELED LIPOSOMES - TARGETED MR CONTRAST AGENTS FOR THE LIVER AND SPLEEN
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DOI：
10.1148/radiology.163.1.3454163
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发表时间：
1987-04-01
期刊：
影响因子：
19.7
通讯作者：
HUANG, L
中科院分区：
文献类型：
--
作者：
KABALKA, G;BUONOCORE, E;HUANG, L
已经设计了一种用于肝和脾的磁共振（MR）成像的造影剂，其中钆-DTPA被化学掺入脂质体颗粒的层状相中。该制剂具有良好的体内稳定性，静脉给药后可被正常小鼠的肝脏和脾脏吸收。在4 ℃下，肝脏中的T1增加了110%，脾脏中增加了66%。在37 °，肝脏的舒张率增加了180%。这种方法是一个有吸引力的概念，用于开发各种器官特异性脂质体造影剂，可用于MR成像或核医学。
A contrast agent for use in magnetic resonance (MR) imaging of the liver and spleen has been designed in which gadolinium-DTPA is chemically incorporated into the lamellar phase of liposome particles. This agent has excellent in vivo stability and is taken up by liver and spleen of normal mice after intravenous administration. The T1 increased by 110% in liver and 66% in spleen at 4.degree.C. At 37.degree., the relaxation rate in the liver increased by 180%. This method is an attractive concept for the development of various organ-specific liposomal contrast agents that may be used for either MR imaging or nuclear medicine.