Light response of the neuronal firing activity in the suprachiasmatic nucleus of mice
Light response of the neuronal firing activity in the suprachiasmatic nucleus of mice
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DOI：
10.1016/j.neulet.2004.09.005
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发表时间：
2004-11-23
影响因子：
2.5
通讯作者：
Shinohara, K
中科院分区：
文献类型：
--
作者：
Nakamura, TJ;Fujimura, K;Shinohara, K
为了研究哺乳动物光诱导昼夜节律的神经机制，研究了麻醉小鼠视交叉上核（SCN）神经元细胞外放电活动对视网膜光刺激的反应。在夜间，大多数记录的SCN细胞（83%）增加了响应视网膜照明的放电频率。一些SCN细胞（11%）通过降低它们的放电率来响应。在白天，视网膜照明增加的放电率只有26%的SCN细胞，并没有观察到在其余的细胞。在Zeitgeber时间（ZT）16时，SCN细胞激活的光强度阈值约为3 × 10（11）光子cm（-2）s（-1），在约1 × 10（14）光子cm（-2）s（-1）时观察到最大响应。因此，小鼠SCN细胞放电中的光响应可能是相位依赖性的，并且具有较高的阈值，这对应于小鼠运动活动中的光夹带的性质。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
To investigate the neural mechanisms underlying the mammalian photic entrainment of circadian rhythms, the response of neuronal extracellular firing activity to retinal light stimulation was investigated in the suprachiasmatic nucleus (SCN) of anesthetized mice during nighttime and daytime. In nighttime, most recorded SCN cells (83%) increased their firing frequency in response to retinal illumination. Some SCN cells (11%) responded by decreasing their firing rate. In daytime, the retinal illumination increased the firing rate in only 26% of the SCN cells, and no response was observed in the remaining cells. The light intensity threshold for the activation of SCN cells at zeitgeber time (ZT) 16 was approximately 3 x 10(11) photons cm(-2) s(-1) and the maximum response was observed at approximately 1 x 10(14) photons cm(-2) s(-1). Therefore, photic response in the firing of mouse SCN cells may be phase-dependent and have a higher threshold, which corresponds to properties of the photic entrainment in locomotor activity of mice. (C) 2004 Elsevier Ireland Ltd. All rights reserved.