An experimental basis for histamine release in contrast material reactions.
An experimental basis for histamine release in contrast material reactions.
复制标题
对比材料反应中组胺释放的实验基础。
作者：
E. Lasser;A. Walters;J. Lang
单独用甲基葡胺造影剂或甲基葡胺氯化物对犬的肝脏或肺进行灌流，会在这些器官流出的血管通道中产生较高的组胺血浆水平。造影剂的钠盐在产生组胺释放方面不如甲基葡胺盐有效。这些研究表明，造影剂诱导组胺释放的阈值效应以及顺序注射的增强效应。使用等量的造影剂，39秒的注射比2秒的注射产生更多的组胺释放。
Perfusion of the canine liver or lung with methylglucamine contrast media or methylglucamine chloride alone will produce elevated histamine plasma levels in the effluent vascular channels from these organs. The sodium salts of the contrast media were less effective than the methylglucamine salts in producing histamine release. These studies suggest a threshold effect for contrast-media-induced histamine release as well as a potentiating effect for sequential injections. Using equal quantities of contrast media, injections over a 39-second period produced greater histamine release than 2-second injections.