Health-related quality of life before and after a breast cancer diagnosis
Health-related quality of life before and after a breast cancer diagnosis
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DOI：
10.1007/s10549-007-9653-1
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发表时间：
2008-05-01
影响因子：
3.8
通讯作者：
Hampton, John M.
中科院分区：
文献类型：
--
作者：
Trentham-Dietz, Amy;Sprague, Brian L.;Hampton, John M.
虽然许多报道描述了乳腺癌幸存者的健康相关生活质量（QOL），但很少有人比较诊断前后的QOL，以及QOL的变化是否与所有女性在衰老过程中经历的变化有很大不同。对威斯康星州的比弗坝的一组女性居民进行了QOL检查，在1988 - 1990年基线检查时年龄为43 - 86岁（N = 2，762;合格人数的83%）。参与者通过2002年重新联系了四次，以确定使用36项简表健康调查（SF-36）的生活质量。通过与全州癌症登记处的数据链接确定的114例乳腺癌病例的QOL数据与2，527名无乳腺癌妇女的数据进行了比较。在SF-36身体健康总结（PCS）量表上，乳腺癌女性平均比对照女性低4.5分（95% CI：1.6，7.3），与诊断后的时间无关（最长13年）。乳腺癌患者在诊断后两年内的SF-36精神成分总结（MCS）量表评分也较低，但在更远的时间内则没有。在纵向分析中，26名在乳腺癌诊断前后完成SF-36的女性在SF-36的8个健康领域中的7个领域中的下降幅度大于年龄匹配的对照组（除角色-情绪外），PCS和MCS量表报告的相对下降分别为-7.0（95% CI：-11.5，-2.6）和-2.9（95% CI：-6.3，0.6）。这些结果表明，乳腺癌幸存者在广泛的领域中经历了健康相关QOL的相对下降，甚至在诊断后多年。
While many reports describe health-related quality of life (QOL) among breast cancer survivors, few compare QOL before and after diagnosis and whether changes in QOL substantially differ from changes experienced by all women during aging. QOL was examined in a cohort of female residents of Beaver Dam, Wisconsin, aged 43 -86 years at the time of a 1988 -1990 baseline examination (N = 2,762; 83% of eligible). Participants were recontacted four times through 2002 to ascertain QOL using the 36-item Short Form Health Survey (SF-36). QOL data for 114 incident breast cancer cases identified by data linkage with the statewide cancer registry were compared with data for 2,527 women without breast cancer. Women with breast cancer averaged 4.5 (95% CI: 1.6, 7.3) points lower than control women on the SF-36 Physical Component Summary (PCS) scale, regardless of time since diagnosis (up to 13 years). Women with breast cancer also reported lower scores on the SF-36 Mental Component Summary (MCS) scale within two years after diagnosis, but not at more distant times. In longitudinal analyses, 26 women who completed the SF-36 before and after breast cancer diagnosis experienced larger declines than age-matched controls in seven of the eight SF-36 health domains (all but role-emotional) and reported relative declines of -7.0 (95% CI: -11.5, -2.6) and -2.9 (95% CI: -6.3, 0.6) on the PCS and MCS scales, respectively. These results suggest that breast cancer survivors experience relative declines in health-related QOL across a broad spectrum of domains, even many years after diagnosis.