Carcinoma of the lung and diffuse interstitial pulmonary fibrosis
Carcinoma of the lung and diffuse interstitial pulmonary fibrosis
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肺癌和弥漫性间质性肺纤维化
DOI：
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发表时间：
1968
影响因子：
3.4
通讯作者：
R. Risdon
中科院分区：
文献类型：
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作者：
B. Fox;R. Risdon
本文报告两例弥漫性肺间质纤维化合并肺癌的临床及病理结果。在1例类风湿性关节炎和弥漫性间质性肺纤维化病例中，存在“恶性肺腺瘤病”，这种相关性以前似乎没有报告过。在第二个病例中，特发性弥漫性肺间质纤维化并发肺大细胞未分化癌。这表明，在这两种情况下，肺癌的发展是一个并发症的上皮增生和瘢痕，发生在弥漫性肺间质纤维化。也有人建议，在弥漫性间质性肺纤维化患者的主支气管发现癌不应被视为巧合，除非仔细搜索已排除癌性变化的疤痕肺的周边。
The clinical and histopathological findings are presented in two cases of diffuse interstitial pulmonary fibrosis in which carcinoma of the lung developed. In one case with rheumatoid arthritis and diffuse interstitial pulmonary fibrosis there was `malignant pulmonary adenomatosis', an association which does not appear to have been reported before. In the second case idiopathic diffuse interstitial pulmonary fibrosis was complicated by large cell anaplastic carcinoma of the lung. It is suggested that in both cases the development of carcinoma of the lung was a complication of the epithelial hyperplasia and scarring that occurs in diffuse interstitial pulmonary fibrosis. It is also suggested that carcinoma found in the main bronchi in patients with diffuse interstitial pulmonary fibrosis should not be regarded as coincidental unless careful search has excluded a carcinomatous change in the periphery of the scarred lungs.