Daily Brazilian green propolis intake elevates blood artepillin C levels in humans
Daily Brazilian green propolis intake elevates blood artepillin C levels in humans
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每日摄入巴西绿蜂胶可提高人体血液中阿替匹林 C 水平
DOI：
10.1002/jsfa.11132
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发表时间：
2021
影响因子：
4.1
通讯作者：
Imaizumi Tadaatsu
中科院分区：
文献类型：
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作者：
Ding Jiangli;Matsumiya Tomoh;Hayakari Ryo;Shiba Yuko;Kawaguchi Shogo;Seya Kazuhiko;Ueno Kayo;Imaizumi Tadaatsu
蜂胶是由工蜂从各种植物中收集的天然产物。巴西绿色蒿作为一种蒿属植物，含有大量的蒿匹林C。阿替匹林C是一种肉桂酸衍生物，已在细胞培养和动物模型中显示具有多种生物学功能，包括抗炎、抗病毒和抗肿瘤活性。然而，如何消化和吸收，仍有待阐明。此外，在人体研究中尚未显示摄入巴西绿青霉素后的血液阿替匹林C水平。在健康志愿者中进行了巴西绿色青霉素对血清阿替匹林C水平影响的随机、单盲安慰剂对照研究。参与者（n= 133）以约2：1的比例随机分配到两组：安慰剂（n= 91）和安慰剂（n= 42）。参与者每天服用安慰剂或安慰剂，并在第0天（服用安慰剂前）和第1天，第3天和第7天进行血液检查。几乎所有的个体在血清中检测到阿替匹林C。安慰剂组未检测到血清阿替匹林C。女性组血清阿替匹林C水平有高于男性组的趋势。在女性组中，月经状态是无关的血清artepillin C levels.CONCLUSIONThese结果表明，青蒿素摄入量可能是更有效的女性比男性。© 2021化学工业协会
BACKGROUNDPropolis is a natural product collected by worker bees from a variety of plant species. As a type of propolis, Brazilian green propolis contains a large amount of artepillin C. Artepillin C is a cinnamic acid derivative and has been shown to have a wide variety of biological functions, including anti‐inflammatory, antiviral and antitumor activities, in both cell culture and animal models. However, how propolis is digested and absorbed remains to be elucidated. Moreover, blood artepillin C levels after propolis intake have not been shown in human studies.RESULTSA randomized, single‐blind placebo‐controlled study on the effect of Brazilian green propolis on serum artepillin C levels was conducted with healthy volunteers. The participants (n= 133) were randomly allocated in an approximately 2:1 ratio to two groups: propolis (n= 91) and placebo (n= 42). The participants took daily propolis or placebo, and blood tests were performed on day 0 (before propolis intake) and days 1, 3 and 7. Artepillin C was detected in serum in almost all individuals in the propolis groups. No serum artepillin C was detected in the placebo group. Serum artepillin C levels in the female group tended to be higher than those in the male group. In the female group, menstrual status was unrelated to serum artepillin C levels.CONCLUSIONThese results suggested that propolis intake might be more effective for females than for males. © 2021 Society of Chemical Industry