Portal and cubital serum insulin during oral, portal and cubital glucose tolerance tests.
Portal and cubital serum insulin during oral, portal and cubital glucose tolerance tests.
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口服、门脉和肘部葡萄糖耐量试验期间的门静脉和肘部血清胰岛素。
作者：
B. Lund;A. Schmidt;T. Deckert
对7名非肥胖非糖尿病患者进行了口服、尿道内和门静脉内葡萄糖耐量试验，并跟踪了外周血和门静脉血中的葡萄糖和胰岛素浓度。口服葡萄糖后1/2-2 min，门脉葡萄糖和胰岛素显著升高。胰岛素和葡萄糖浓度的上升之间没有滞后。口服葡萄糖摄入后的门静脉葡萄糖浓度显著高于肘静脉葡萄糖输注45分钟后，尽管外周葡萄糖浓度相同。在肘静脉中，口服葡萄糖摄入后的胰岛素浓度显著高于静脉输注葡萄糖后的胰岛素浓度，但在门静脉血中没有差异。门静脉输注葡萄糖后，肘关节胰岛素浓度与静脉输注葡萄糖后的浓度无显著差异。因此，口服葡萄糖后外周血胰岛素浓度升高似乎不太可能是门静脉葡萄糖浓度升高所致。门静脉葡萄糖浓度高似乎不影响肝脏摄取或释放葡萄糖。
Oral, intracubital, and intraportal glucose tolerance tests have been performed on 7 non-obese non-diabetics, and glucose and insulin concentrations have been followed in the peripheral and portal blood. A significant rise in portal glucose and insulin was found 1/2-2 min after oral glucose intake. There was no lag between the rise in insulin and glucose concentrations. The portal glucose concentration after oral glucose intake was significantly higher than after cubital glucose infusion for 45 min, although the peripheral glucose concentrations were identical. In the cubital vein the insulin concentration after oral glucose intake was significantly higher than after i.v. glucose infusion, but in the portal blood there was no difference. After portal glucose infusion the cubital insulin concentration did not differ significantly from the concentration after i.v. glucose infusion. Thus, it seems unlikely that a high portal glucose concentration is responsible for the higher peripheral insulin concentration after oral glucose intake. A high portal glucose concentration does not seem to influence the hepatic uptake or release of glucose.