Heritability of frontal brain function related to action monitoring
Heritability of frontal brain function related to action monitoring
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DOI：
10.1111/j.1469-8986.2008.00664.x
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发表时间：
2008-07-01
期刊：
影响因子：
3.7
通讯作者：
Heath, Andrew C.
中科院分区：
文献类型：
--
作者：
Anokhin, Andrey P.;Golosheykin, Simon;Heath, Andrew C.
监控预期动作与实际执行动作之间的对应关系是行为调节的基本机制，由错误相关负性 (ERN) 反映，ERN 是由前扣带皮层生成的 ERP 组件。这项研究检查了遗传对 ERN 和与动作监控相关的其他组成部分（正确负性，CRN 和错误正性，P-e）的影响。对青春期双胞胎（12 岁）进行侧翼任务，其中包括 99 对同卵双胞胎 (MZ) 和 175 对双卵双胞胎 (DZ)。遗传分析显示所有三个 ERP 成分均具有显着的遗传力 (40%-60%)，并且它们之间具有显着的遗传相关性。这项研究为动作监测的神经基质中可遗传的个体差异提供了第一个证据，并表明 ERN、CRN 和 P-e 有可能作为与行为异常调节相关的人格特质和精神病理学的遗传研究的内表型。
Monitoring the correspondence between the intended and actually executed action, a fundamental mechanism of behavioral regulation, is reflected by error-related negativity (ERN), an ERP component generated by the anterior cingulate cortex. This study examined genetic influences on the ERN and other components related to action monitoring (correct negativity, CRN, and error positivity, P-e). A flanker task was administered to adolescent twins (age 12) including 99 monozygotic (MZ) and 175 dizygotic (DZ) pairs. Genetic analysis showed substantial heritability of all three ERP components (40%-60%) and significant genetic correlations between them. This study provides the first evidence for heritable individual differences in the neural substrates of action monitoring and suggests that ERN, CRN, and P-e can potentially serve as endophenotypes for genetic studies of personality traits and psychopathology associated with abnormal regulation of behavior.