Susceptibility to infections and immune status in Inuit infants exposed to organochlorines
Susceptibility to infections and immune status in Inuit infants exposed to organochlorines
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DOI：
10.2307/3454435
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发表时间：
2000-03-01
影响因子：
10.4
通讯作者：
Roy, R
中科院分区：
文献类型：
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作者：
Dewailly, É;Ayotte, P;Roy, R
我们调查了有机氯暴露是否与努纳维克（加拿大北极魁北克）因纽特婴儿传染病的发病率有关。我们收集了98名母乳喂养婴儿和73名人工喂养婴儿在出生后第一年内的传染病发作次数。在早期母乳样本中测量了有机氯的浓度，并将其用作产前接触水平的替代品。免疫系统参数测定静脉血样本收集的婴儿在3个月，7个月和12个月大。中耳炎是最常见的疾病，80.0%的母乳喂养婴儿和81.3%的奶瓶喂养婴儿在出生后第一年内至少经历过一次发作。在第二次随访期间，中耳炎的风险增加与产前暴露于p，p '-DDE，六氯苯，狄氏剂。与最低三分位数的婴儿相比，p，p '-DDE暴露量最高三分位数的4至7个月大婴儿的相对风险（RR）为1.87 [95%置信区间（CI），1.07-3.26]。出生后第一年内中耳炎的发病率也随着产前暴露于p，p '-DDE（RR，1.52; CI，1.05-2.22）和六氯苯（RR，1.49; CI，1.10-2.03）而增加。此外，复发性中耳炎（大于或等于3次发作）的RR随着产前暴露于这些化合物而增加。母乳喂养和人工喂养的婴儿在免疫学参数方面没有临床相关差异，产前有机氯暴露与免疫学参数无关。我们的结论是，产前有机氯暴露可能是因纽特婴儿急性中耳炎的危险因素。
We investigated whether organochlorine exposure is associated with the incidence of infectious diseases in Inuit infants from Nunavik (Arctic Quebec, Canada). We compiled the number of infectious disease episodes during the first year of life for 98 breast-fed and 73 bottle-fed infants. Concentrations of organochlorines were measured in early breast milk samples and used as surrogates to prenatal exposure levels. Immune system parameters were determined in venous blood samples collected from infants at 3, 7, and 12 months of age. Otitis media was the most frequent disease, with 80.0% of breast-fed and 81.3% of bottle-fed infants experiencing at least one episode during the first year of life. During the second follow-up period, the risk of otitis media increased with prenatal exposure to p,p'-DDE, hexachlorobenzene, and dieldrin. The relative risk (RR) for 4- to 7-month-old infants in the highest tertile of p,p'-DDE exposure as compared to infants in the lowest tertile was 1.87 [95% confidence interval (CI), 1.07-3.26]. The RR of otitis media over the entire first year of life also increased with prenatal exposure to p,p'-DDE (RR, 1.52; CI, 1.05-2.22) and hexachlorobenzene (RR, 1.49; CI, 1.10-2.03). Furthermore, the RR of recurrent otitis media (greater than or equal to 3 episodes) increased with prenatal exposure to these compounds. No clinically relevant differences were noted between breast-fed and bottle-fed infants with regard to immunologic parameters, and prenatal organochlorine exposure was not associated with immunologic parameters. We conclude that prenatal organochlorine exposure could be a risk factor for acute otitis media in Inuit infants.