EVIDENCE AGAINST THE ASSOCIATION BETWEEN ALCOHOL-USE AND ISCHEMIC STROKE RISK
EVIDENCE AGAINST THE ASSOCIATION BETWEEN ALCOHOL-USE AND ISCHEMIC STROKE RISK
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DOI：
10.1001/archinte.149.6.1413
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发表时间：
1989-06-01
影响因子：
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通讯作者：
HORWITZ, RI
中科院分区：
文献类型：
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作者：
HENRICH, JB;HORWITZ, RI
为了检验饮酒与缺血性卒中风险之间的关系，我们使用了斯托克风险病例对照研究的数据。89例入院的缺血性中风患者的头部计算机断层扫描记录匹配到178个控制。酒精使用的定义是对习惯使用的估计（重度、中度、轻度或无）。我们没有发现任何水平的饮酒与缺血性卒中风险之间存在一致或显著的相关性（比值比：任何，1.3;重度，0.5;中度，1.5;轻度，1.5）。我们使用对照组重复分析我们的研究，对照组根据另一项病例对照研究的研究标准组装，该研究报告了男性重度饮酒的显着相关性（比值比，4.2）。我们证明了先前研究中的相关性可能是由于方法学问题造成的虚假。
To examine the relationship between alcohol consumption and ischemic stroke risk, we used data from our case-control study of stoke risk. Eighty-nine patients admitted to the hospital with ischemic stroke documented by computed tomography of the head were matched to 178 controls. Alcoholic use was defined by an estimate of customary use (heavy, moderate, light, or none). We found no consistent or significant association between any level of alcohol use and ischemic stroke risk (odds ratios: any, 1.3; heavy, 0.5; moderate, 1.5; and light, 1.5). We repeated the analysis of our study using a control group assembled according to the study criteria of another case-control study that reported a significant association in men with heavy alcohol use (odds ratio, 4.2). We demonstrated that the association in the prior study may be spurious due to methodological problems.