Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG Adherence Instruments
Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG Adherence Instruments
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DOI：
10.1080/09540120050042891
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发表时间：
2000-06-01
影响因子：
1.7
通讯作者：
Wu, AW
中科院分区：
文献类型：
--
作者：
Chesney, MA;Ickovics, JR;Wu, AW
本文介绍了AACTG依从性工具，其中包括两个自我报告的问卷，用于成人艾滋病临床试验组（AACTG）进行的临床试验。在美国的10个AACTG站点对75名患者进行了问卷调查。所有患者均接受联合抗逆转录病毒治疗（ART），包括至少一种蛋白酶抑制剂。11%的患者报告在访谈前一天至少漏服一剂，17%的患者报告在前两天至少漏服一剂。错过药物的最常见原因包括“只是忘记了”（66%）和一些通常与改善健康有关的因素，包括忙碌（53%），离家（57%）和日常生活的变化（51%）。依从性较低的患者报告依从性自我效能较低（p = 0.006），并且不太确定不依从性与耐药发生之间的联系（p = 0.009）。他们也更有可能饮酒，更有可能在家庭外工作并参加临床试验以获得药物（所有p < 0.05）。22%服用需要特别说明的药物的病人不知道这些说明。每份问卷大约需要10分钟完成。对调查表的答复是积极的。迄今为止，这些问卷已被纳入六项AACTG临床试验，并已广泛传播给美国和国外的研究人员。
This paper describes the AACTG Adherence Instruments, which are comprised of two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antiretroviral therapy (ART), including at least one protease inhibitor. Eleven per cent of patients reported missing at least one dose the day before the interview, and 17% reported missing at least one dose during the two days prior. The most common reasons for missing medications included 'simply forgot' (66%) and a number of factors often associated with improved health, including being busy (53%), away from home (57%) and changes in routine (51%). Less adherent patients reported lower adherence self-efficacy (p = 0.006) and were less sure of the link between non-adherence and the development of drug resistance (p = 0.009). They were also more likely to consume alcohol, to be employed outside the home for pay and to have enrolled in clinical trials to gain access to drugs (all p < 0.05). Twenty-two per cent of patients taking drugs requiring special instructions were unaware of these instructions. Each questionnaire took approximately ten minutes to complete. Responses to the questionnaires were favourable. These questionnaires have been included in six AACTG clinical trials to date and have been widely disseminated to investigators both in the USA and abroad.