Template-based protein structure modeling.
Template-based protein structure modeling.
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DOI：
10.1007/978-1-60761-842-3_6
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Fiser A
中科院分区：
文献类型：
--
作者：
Fiser A
蛋白质的功能表征通常通过其3D结构来促进。然而，由于结构确定技术固有的耗时和复杂性，实验已知的3D模型的比例目前小于1%。采用计算方法来弥合已知序列的数量与3D模型的数量之间的差距。基于模板的蛋白质结构建模技术依赖于从进化论的角度研究天然蛋白质的三维结构。基于模板的结构建模的策略将重点讨论比较建模，通过回顾可用于比较建模管道中涉及的所有主要步骤的技术。
Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.