Prolonged exposure to high humidity and high temperature environment can aggravate influenza virus infection through intestinal flora and Nod/RIP2/NF-κB signaling pathway
Prolonged exposure to high humidity and high temperature environment can aggravate influenza virus infection through intestinal flora and Nod/RIP2/NF-κB signaling pathway
复制标题
长时间暴露于高湿、高温环境可通过肠道菌群和Nod/RIP2/NF-kappaB信号通路加重流感病毒感染。
DOI：
10.1016/j.vetmic.2020.108896
复制
发表时间：
2020-12-01
影响因子：
3.3
通讯作者：
Chen, Xiaoyin
中科院分区：
文献类型：
--
作者：
Deng, Li;Xu, Huachong;Chen, Xiaoyin
季节性流感是由流感病毒引起的急性病毒感染，常在夏季和冬季流行。流感病毒可以感染猪和家禽。有文献报道流感病毒在夏季有暴发流行。夏季气候的特点是高湿高温环境，这与许多动物的饲养和生长环境相同。我们在白天高温高湿环境下建立流感动物模型，观察高湿高温环境对小鼠感染流感病毒后的影响。结果表明，高湿高温环境下培养的猪肠道16 s rDNA植物群发生变化，肠粘膜通透性增加，肠粘膜免疫系统中pIgR、sIgA、伊加表达减少，NLR免疫识别信号通路NOD 1被激活。NOD 2、NF-κ B、pIgR等相关基因表达增加，导致肠道附近相关炎症因子增加，加重局部炎症。高湿高温环境可引起体内炎性细胞因子表达升高，引起Th 17/Treg免疫失衡，抑制Treg成熟和分化，使IL-2、IL-6等细胞因子表达增加，而IFN-γ和IL-17 A表达减少。这种情况是在感染流感病毒后出现的。总体而言，我们的研究发现，高湿高温环境影响肠道植物群和机体的免疫状态，从而加重流感病毒的感染状况。
Seasonal influenza is an acute viral infection caused by influenza virus, which is often prevalent in the summer and winter. The influenza virus can infect pigs and poultry. Some literature reports that the influenza virus has an outbreak in summer. The summer climate is characterized by a high humidity and high temperature environment, which is the same as many animal feeding and growing environments. We established a flu animal model under a high temperature and humidity environment during the day to observe the impact of high humidity and high temperature environment on the mice after contracting the influenza virus. Our results indicate that the intestinal flora of 16 s rDNA cultured in High humidity and high temperature environment changes, the intestinal mucosal permeability increases, the expression of pIgR, sIgA, and IgA in the intestinal mucosal immune system decreases, and the NLR immune recognition signaling pathway NOD1 is activated. The expression of related genes such as NOD2, NF-kappa B, and pIgR increases, which leads to the increase of related inflammatory factors in the vicinity of the intestines, aggravating local inflammation. High humidity and high temperature environment can cause the expression of inflammatory cytokines in the body to rise, causing Th17/Treg immune imbalance, inhibiting Treg maturation and differentiation, and increasing the expression of IL-2, IL-6, and other cytokines, while the expression of IFN-gamma and IL-17A decreases. This condition worsens after infection with the influenza virus. Overall, our study found that High humidity and high temperature environment affect the intestinal flora and the body's immune status, thereby aggravating the status of influenza virus infection.