Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects
Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects
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DOI：
10.1176/ajp.155.10.1384
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发表时间：
1998-10-01
影响因子：
17.7
通讯作者：
McCarley, RW
中科院分区：
文献类型：
--
作者：
Hirayasu, Y;Shenton, ME;McCarley, RW
目的：精神分裂症患者的磁共振成像（MRI）研究显示了脑结构异常，左后上级颞回和内侧颞长袍结构中灰质体积较低。然而，精神分裂症的特异性以及慢性发病率和抗精神病药物治疗在这些异常中的作用仍不清楚。方法：磁共振（1.5-T）扫描获得了33例首发精神病患者和18名年龄匹配的正常对照组，所有的右手。其中16名患者被诊断为情感障碍，17名患者被诊断为精神分裂症。结果如下：定量体积分析显示，首发精神分裂症患者左侧后上级颞回灰质体积明显小于首发情感性精神病患者或对照组，具有明显的左小于右不对称性。精神分裂症患者的左后杏仁核-海马复合体的灰质体积也比对照组小。精神分裂症患者和情感性精神病患者的杏仁核-海马复合体后部结构均存在显著的左小于右不对称性。结论：这些结果表明，颞叶异常存在于首次住院精神分裂症和低容量的左后上级颞回灰质是特定的精神分裂症相比，情感障碍。
Objective: Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes of gray matter in the left posterior superior temporal gyrus and in medial temporal robe structures. However, the specificity to schizophrenia and the roles of chronic morbidity and neuroleptic treatment in these abnormalities remain unclear. Method: Magnetic resonance (1.5-T) scans were obtained from 33 patients with first-episode psychosis and 18 age-matched normal comparison subjects, all right-handed. Sixteen of the patients were diagnosed with affective disorder and 17 with schizophrenia. Results: Quantitative volumetric analysis showed that the patients with first-episode schizophrenia had significantly smaller gray matter volume in the left posterior superior temporal gyrus than did the patients with first-episode affective psychosis or the comparison subjects, with a significant left-less-than-right asymmetry. The schizophrenic patients also showed a smaller gray matter volume of the left posterior amygdala-hippocampal complex than the comparison subjects. Both the patients with schizophrenia and those with affective psychosis had significant left-less-than-right asymmetry of the posterior amygdala-hippocampal complex. Conclusions: These findings suggest that temporal lobe abnormalities are present at the first hospitalization for schizophrenia and that low volume of the left posterior superior temporal gyrus gray matter is specific to schizophrenia compared with affective disorder.