CALORIE-PROVIDING NUTRIENTS AND RISK OF BREAST-CANCER
CALORIE-PROVIDING NUTRIENTS AND RISK OF BREAST-CANCER
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DOI：
10.1093/jnci/81.4.278
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发表时间：
1989-02-15
影响因子：
10.3
通讯作者：
CAPPA, APM
中科院分区：
文献类型：
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作者：
TONIOLO, P;RIBOLI, E;CAPPA, APM
在意大利进行了一项病例对照研究，以调查饮食在乳腺癌中的作用。病例是250名患有乳腺癌的女性，对照组是从普通人群中分层随机抽样的499名女性。饮食历史问卷被用来测量总脂肪、饱和脂肪、动物蛋白和其他常量营养素的摄入量。在多变量分析中，摄入饱和脂肪和动物蛋白最高五分之一的女性患乳腺癌的相对风险分别为3.0(95%可信区间，1.9-4.7)和2.9(1.8-4.6)。研究发现，从脂肪中摄取28%卡路里的女性比从36%卡路里中摄取卡路里的女性风险更低。从饱和脂肪中摄取9.6%卡路里或从动物蛋白中摄取5.9%卡路里的女性，患病风险也有类似的降低。这些数据表明，在成年期间，减少动物来源的脂肪和蛋白质的饮食摄入量可能有助于大幅降低动物产品摄入量较高的人群亚群中乳腺癌的发病率。
A case-control study was conducted in Italy to investigate the role of diet in breast cancer. Cases were 250 women with breast cancer, and controls were a stratified random sample of 499 women from the general population. A dietary history questionnaire was used to measure the intake of total fat, saturated fat, animal proteins, and other macronutrients. In multivariate analyses, the relative risks of breast cancer for women in the highest quintile of consumption of saturated fat and animal proteins were 3.0 (95% confidence interval, 1.9-4.7) and 2.9 (1.8-4.6), respectively. A reduced risk was found for women who derived < 28% of calories from fat versus > 36%. A similarly reduced risk was found for women who derived < 9.6% of calories from saturated fat or < 5.9% from animal proteins. These data suggest that during adult life, a reduction in dietary intake of fat and proteins of animal origin may contribute to a substantial reduction in the incidence of breast cancer in population subgroups with high intake of animal products.