Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population
Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population
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DOI：
10.1093/aje/kwg191
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发表时间：
2003-10-01
影响因子：
5
通讯作者：
Knowler, WC
中科院分区：
文献类型：
--
作者：
Kriska, AM;Saremi, A;Knowler, WC
这项研究考察了高危人群中体力活动、体重指数和 2 型糖尿病发展之间的纵向关系，其独特之处在于糖尿病是通过口服葡萄糖耐量测试而不是通过自我报告来确定的。作为 1987 年至 2000 年在吉拉河印第安社区进行的一系列临床检查的一部分，对 1,728 名年龄在 15-59 岁的非糖尿病皮马人进行了身体活动调查问卷，评估过去一年的休闲和职业活动。在平均 6 年的随访期间，346 名受试者患上了糖尿病。作者使用时间相关的 Cox 比例风险模型调整年龄，发现总活动量与女性和男性的糖尿病发病率相关（仅在女性中 p < 0.05）。对体重指数进行额外调整后，男性和女性的活动与糖尿病发病率之间的关系均减弱。当通过按体重指数三分位数分层的活动水平来检查年龄调整的糖尿病发病率时，所有体重指数组中活跃度较高的男性和女性的糖尿病发病率仍然低于活跃度较低的男性和女性，但男性中体重指数三分位除外（仅女性中 p < 0.05）。这些结果表明，采取和维持积极的生活方式可以在预防 2 型糖尿病方面发挥重要作用。
This study, examining the longitudinal relation among physical activity, body mass index, and development of type 2 diabetes in a high-risk population, is unique because diabetes was determined by oral glucose tolerance testing rather than by self-report. A physical activity questionnaire assessing past year leisure and occupational activity was administered to 1,728 nondiabetic Pima individuals aged 15-59 years as part of a series of clinic examinations in the Gila River Indian Community from 1987 to 2000. During an average follow-up period of 6 years, 346 subjects developed diabetes. Using time-dependent Cox proportional hazards modeling adjusting for age, the authors found that total activity was related to diabetes incidence in women and men (p < 0.05 in women only). After additional adjustment for body mass index, the relation between activity and diabetes incidence was weakened in both men and women. When the age-adjusted diabetes incidence rates were examined by levels of activity stratified by tertile of body mass index, the diabetes incidence rate remained lower in more active than in less active men and women from all body mass index groups, with the exception of the middle body mass index tertile in men (p < 0.05 in women only). These results suggest that the adoption and maintenance of a physically active lifestyle can play a significant role in preventing type 2 diabetes.