Signal transduction: stuck with FYVE domains.
Signal transduction: stuck with FYVE domains.
复制标题
DOI：
10.1126/stke.2000.37.pe1
复制
发表时间：
2000-06-20
期刊：
影响因子：
--
通讯作者：
Corvera, S
中科院分区：
文献类型：
--
作者：
Corvera, S
FYVE结构域是允许胞质蛋白与含有脂质磷脂酰肌醇3-磷酸的膜相互作用的蛋白基序。有关FYVE结构域的结构信息来自两种晶体结构和NMR分析。Corvera讨论了这些结构如何不同，以及它们告诉我们具有FYVE结构域的蛋白质如何与生物膜相互作用。该观点还涉及如何与FYVE结构域和蛋白质内化的蛋白质参与信号转导。
The FYVE domain is a protein motif that allows the interaction of cytosolic proteins with membranes containing the lipid phosphatidylinositol 3-phosphate. Structural information about FYVE domains has come from two crystal structures and NMR analysis. Corvera discusses how these structures differ and what they tell us about how proteins with FYVE domains interact with biological membranes. The Perspective also addresses how proteins with FYVE domains and protein internalization are involved in signal transduction.