Distribution of dopamine D3 receptor expressing neurons in the human forebrain:: Comparison with D2 receptor expressing neurons
Distribution of dopamine D3 receptor expressing neurons in the human forebrain:: Comparison with D2 receptor expressing neurons
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DOI：
10.1016/s0893-133x(98)00066-9
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发表时间：
1999-01-01
影响因子：
7.6
通讯作者：
Joyce, JN
中科院分区：
文献类型：
--
作者：
Gurevich, EV;Joyce, JN
多巴胺D-2和D-3受体是包括D-2、D-3和D-4受体的D-2亚家族的成员。在mt中，D-3受体表现出局限于中脑边缘区的分布，与D-2受体几乎没有重叠。受体结合和非同位素原位杂交被用来研究的D-3受体和神经元的D-3 mRNA阳性的分布相比，D-2受体/mRNA在人脑皮层下区域。D-2结合位点分布于所有脑区，以纹状体最高，其次是下丘脑的丘脑底核、苍白球外段、黑质和腹侧被盖区、内侧视前区和结节乳头核。在大多数地区的D-2受体网站的存在下，正好与其mRNA阳性的神经元的存在。D-3结合位点和D-3 mRNA阳性神经元主要分布在边缘纹状体和传出结构，如中脑腹侧核、纹状体腹侧、黑质、苍白球内段、丘脑前腹侧核和黑质网状部吻侧。与大鼠的一个重要区别是，在腹侧被盖区几乎不存在D-3受体。D-3受体和D-3 mRNA阳性神经元观察到的感觉，激素，和协会的区域，如基底核，前腹，背内侧，和膝状核的丘脑，乳头核，基底外侧基底内侧，和皮质核的杏仁核。同时标记D-3和D-2 mRNA发现，D-3 mRNA常表达于D-2 mRNA阳性神经元。仅表达D-2 mRNA的神经元数量众多，分布广泛，而仅偶尔观察到D-3阳性-D-2阴性细胞。D-3受体及其mRNA表达相对较高的区域似乎通过功能回路连接，但D-2和D-3 mRNA的共表达表明两种受体亚型介导的信号在许多区域的功能收敛。[Neuropsychopharmacology 20：60-80，1999]（C）1998年美国神经精神药理学学会。爱思唯尔科学公司出版
The dopamine D-2 and D-3 receptors are members of the D-2 subfamily that includes the D-2, D-3 and D-4 receptor. In the mt, the D-3 receptor exhibits a distribution restricted to mesolimbic regions with little overlap with the D-2 receptor. Receptor binding and nonisotopic in situ hybridization were used to study the distribution of the D-3 receptors and neurons positive for D-3 mRNA in comparison to the D-2 receptor/mRNA in subcortical regions of the human brain. D-2 binding sites were detected in all brain areas studied, with the highest concentration found in the striatum followed by the nucleus accumbens, external segment oft he globus pallidus, substantia nigra and ventral tegmental area, medial preoptic area and tuberomammillary nucleus of the hypothalamus. In most areas the presence of D-2 receptor sites coincided with the presence of neurons positive for its mRNA. D-3 binding sites and D-3 mRNA positive neurons were most abundant in the limbic striatum and efferent structures, such as the nucleus accumbens, ventral striatum, substantia nigra, internal segment of the globus pallidus, anteroventral nucleus of the thalamus, and rostral pars reticulata of the substantia nigra. One important difference from the rat is that D-3 receptors were virtually absent in the ventral tegmental area. D-3 receptor and D-3 mRNA positive neurons were observed in sensory, hormonal, and association regions such as the nucleus basalis, anteroventral, mediodorsal, and geniculate nuclei of the thalamus, mammillary nuclei, the basolateral basomedial, and cortical nuclei of the amygdala. As revealed by simultaneous labeling for D-3 and D-2 mRNA, D-3 mRNA tons often expressed in D-2 mRNA positive neurons. Neurons that solely expressed D-2 mRNA were numerous and regionally widespread, whereas only occasional D-3-positive-D-2-negative cells were observed. The regions of relatively higher expression of the D-3 receptor and its mRNA appeared linked through functional circuits, but co-expression of D-2 and D-3 mRNA suggests a functional convergence in many regions of the signals mediated by the two receptor subtypes. [Neuropsychopharmacology 20:60-80, 1999] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.