The relationship of plasma catestatin concentrations with metabolic and vascular parameters in untreated hypertensive patients: Influence on high-density lipoprotein cholesterol.
The relationship of plasma catestatin concentrations with metabolic and vascular parameters in untreated hypertensive patients: Influence on high-density lipoprotein cholesterol.
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DOI：
10.5152/akd.2014.5536
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发表时间：
2015-07
影响因子：
1.3
通讯作者：
Çiçek Y
中科院分区：
文献类型：
--
作者：
Durakoğlugil ME;Ayaz T;Kocaman SA;Kırbaş A;Durakoğlugil T;Erdoğan T;Çetin M;Şahin OZ;Çiçek Y
除减少交感神经-肾上腺血流外，Catestatin还有几种心血管作用。血浆前列腺素水平降低可能反映出高血压和代谢紊乱的易感性。我们计划研究睾丸素在未经治疗的高血压患者中的可能作用。作为次要目的，我们比较了健康受试者和高血压患者的catestatin浓度，以了解catestatin在发病时是反应性增加还是减少。我们的研究是横断面和观察性的。患者组包括109名连续未经治疗且无其他系统性或冠心病的高血压患者，接受血浆睾酮素、腰围、脂质参数、左心室质量、颈动脉内膜-中膜厚度和肱动脉血流介导扩张的评估。此外，我们使用商用酶联免疫吸附测定试剂盒测量了38名表面健康且无任何疾病的受试者的catestatin浓度。我们记录了与健康对照组相比，未经治疗的高血压患者睾酮素浓度升高（2.27±0.83对1.92±0.49 ng/mL, p=0.004）。然而，在调整年龄、性别、身高和体重后，这种关联变得不显著。在患者组中，女性的睾丸素水平明显较高。在所有研究参数中，年龄、高密度脂蛋白胆固醇（HDL-C）与血浆catestatin呈正相关，而甘油三酯、血红蛋白和左心室质量与血浆catestatin负相关。我们没有发现血管参数和睾丸素之间的关联。Catestatin水平随HDL-C升高而显著升高（HDL-C <40、40-60和> 60mg /dL患者分别为1.91±0.37、2.26±0.79和3.1±1.23 ng/mL）。多元线性回归分析显示，年龄（β: 0.201, p=0.041）和HDL-C （β: 0.390, p<0.001）是血浆catestatin浓度的独立相关因素。此外，男性（β:-0.330, p=0.001）和血浆前列腺素（β: 0.299, p=0.002）与HDL-C浓度显著相关。我们证明血浆前列腺素是高密度脂蛋白胆固醇的独立预测因子。除了降压作用，catestatin似乎与改善血脂和代谢谱有关。低睾丸素水平与低HDL-C共存可能为低HDL-C对高血压和心血管事件增加的预测价值提供了可能的机制。
Catestatin has several cardiovascular actions, in addition to diminished sympatho-adrenal flow. Decreased plasma catestatin levels may reflect a predisposition for the development of hypertension and metabolic disorders. We planned to investigate the possible roles of catestatin in untreated hypertensive patients. As a secondary objective, we compared catestatin concentrations of healthy subjects with those of hypertensive patients in order to understand whether catestatin is increased reactively or diminished at onset. Our study was cross-sectional and observational. The patient group, comprising 109 consecutive untreated hypertensive patients without additional systemic or coronary heart disease, underwent evaluations of plasma catestatin, waist circumference, lipid parameters, left ventricular mass, carotid intima-media thickness, and flow-mediated dilation of the brachial artery. Additionally, we measured catestatin concentrations of 38 apparently healthy subjects without any disease using a commercial enzyme-linked immunosorbent assay kit. We documented increased catestatin concentrations in previously untreated hypertensive patients compared to healthy controls (2.27±0.83 vs. 1.92±0.49 ng/mL, p=0.004). However, this association became insignificant after adjustments for age, gender, height, and weight. Within the patient group, catestatin levels were significantly higher in females. Among all study parameters, age, high-density lipoprotein cholesterol (HDL-C) correlated positively to plasma catestatin, whereas triglycerides, hemoglobin, and left ventricular mass correlated negatively to plasma catestatin. We could not detect an association between vascular parameters and catestatin. Catestatin levels were significantly elevated with increasing HDL-C (1.91±0.37, 2.26±0.79, and 3.1±1.23 ng/mL in patients with HDL-C <40, 40-60, and >60 mg/dL, respectively). Multiple linear regression analysis revealed age (beta: 0.201, p=0.041) and HDL-C (beta: 0.390, p<0.001) as independent correlates of plasma catestatin concentration. Additionally, male gender (beta:-0.330, p=0.001) and plasma catestatin (beta: 0.299, p=0.002) were significantly associated with HDL-C concentrations. We documented that plasma catestatin is an independent predictor of high-density lipoprotein cholesterol. In addition to antihypertensive effects, catestatin appears to be related to improved lipid and metabolic profiles. Coexistence of low catestatin levels with low HDL-C may provide a probable mechanism for the predictive value of low HDL-C for increased hypertension and cardiovascular events.