Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α‐NaYF4:Yb,Tm)/CaF2 Core/Shell Nanoparticles for In situ Real‐time Recorded Biocompatible Photoactivation (Small 19/2013)
Upconversion: Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (α‐NaYF4:Yb,Tm)/CaF2 Core/Shell Nanoparticles for In situ Real‐time Recorded Biocompatible Photoactivation (Small 19/2013)
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DOI：
10.1002/smll.201370117
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发表时间：
2013-10
期刊：
影响因子：
13.3
通讯作者：
Jie Shen;Guanying Chen;Tymish Y. Ohulchanskyy;S. Kesseli;Steven Buchholz;Zhipeng Li;P. Prasad
中科院分区：
文献类型：
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作者：
Jie Shen;Guanying Chen;Tymish Y. Ohulchanskyy;S. Kesseli;Steven Buchholz;Zhipeng Li;P. Prasad
上转换纳米粒子（UCNPs）可以将可穿透组织的近红外光转换为紫外光发射，使其成为生物学中光活化的传感器。然而，UV发射UCNP的选择是有限的，并且它们的NIR至UV效率低。G. Han及其同事通过开发具有可调UV增强的CaF2涂层UCNP家族来解决这个问题。如第3213页所报道的，这种设计优于已知的最佳UCNP，并且首次用这种纳米颗粒记录了原位实时活细胞光活化。这一结果是生命系统中光活化的潜在游戏规则改变者，也是其他生物光子应用的新工具。
Upconversion nanoparticles (UCNPs) can convert tissue-penetrable nearinfrared light into UV emission, making them promising as transducers for photoactivation in biology. However, the choice of the UV emitting UCNPs is limited and their NIR-to-UV efficiency is low. G. Han and co-workers have addressed this issue by developing a family of CaF2-coated UCNPs with tunable UV enhancement. As reported on page 3213, such design outperforms known optimal UCNPs and in situ realtime live-cell photoactivation is recorded for the first time with such nanoparticles. This result is a potential game changer in photoactivation in living systems and a new tool for other biophotonic applications.