Intrathymic and extrathymic clonal deletion of T cells.

Intrathymic and extrathymic clonal deletion of T cells.
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T 细胞的胸腺内和胸腺外克隆删除。

DOI:
10.1016/0952-7915(95)80004-2
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发表时间:
1995
影响因子:
7
通讯作者:
Webb,SR
Webb,SR
中科院分区:
医学2区
文献类型:
--
作者:
Sprent,J;Webb,SR

文献摘要

被引文献

相似文献

克隆消除解释了胸腺中的自身耐受诱导,并且还影响了外周中对外源性抗原应答的成熟T细胞。最近的证据上的微环境,细胞间的相互作用和信号转导的要求克隆删除的未成熟和成熟的T细胞进行了讨论。
Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell—cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.