Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.
Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.
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DOI：
10.4155/fso.15.2
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发表时间：
2015-11
影响因子：
2.5
通讯作者：
Maeda H
中科院分区：
文献类型：
--
作者：
Fang J;Liao L;Yin H;Nakamura H;Subr V;Ulbrich K;Maeda H
评价肿瘤靶向纳米探针N-（2-羟丙基）甲基丙烯酰胺共聚物偶联锌原卟啉（PZP）用于光动力学治疗（PDT）和肿瘤成像的潜力。采用不同的肿瘤模型，包括致癌剂诱发的肿瘤，PZP静脉注射，然后用氙气或蓝色荧光灯照射肿瘤。在不同的肿瘤模型中，一次PZP 20 mg/kg（ZnPP当量）剂量与两次或三次强度≥20 J/cm 2的光治疗引起大多数肿瘤坏死和消失（>70%）。我们还在致癌物诱导的乳腺癌和结肠癌模型中证实了基于PZP的肿瘤成像。这些发现支持PZP作为PDT以及肿瘤成像的肿瘤选择性纳米探针的潜在应用，凭借增强的渗透性和保留效应。为了评估肿瘤靶向纳米探针、PZP和普通氙光源用于光动力治疗和肿瘤成像的潜力，使用了不同的肿瘤模型，包括由致癌物诱导的癌症。在所有模型中，静脉注射PZP后发现肿瘤内有较高的蓄积，导致显著的治疗效果。这些发现支持进一步的研究，以评估PZP作为未来纳米药物在食管，乳腺，肺，结肠，直肠，膀胱和宫颈癌中的光动力癌症治疗和成像的潜在应用。
To evaluate the potential of tumor-targeted nanoprobe, N-(2-hydroxypropyl)methacrylamide copolymer-conjugated zinc protoporphyrin (PZP) for photodynamic therapy (PDT) and tumor imaging. Different tumor models including carcinogen-induced cancer were used, PZP was intravenously injected followed by irradiation with xenon or blue fluorescent light on tumor. One PZP 20 mg/kg (ZnPP equivalent) dose with two or three treatments of light at an intensity of ≥20 J/cm2 caused necrosis and disappearance of most tumors (>70%) in different tumor models. We also confirmed PZP-based tumor imaging in carcinogen-induced breast tumor and colon cancer models. These findings support the potential application of PZP as a tumor-selective nanoprobe for PDT as well as tumor imaging, by virtue of the enhanced permeability and retention effect. To evaluate the potential of a tumor-targeted nanoprobe, PZP and normal xenon light source for photodynamic therapy and tumor imaging, different tumor models including cancer induced by carcinogen were used. In all models, a high accumulation of PZP in tumor was found after intravenous injection, resulting in remarkable therapeutic effect. These findings support further research to assess the potential application of PZP as a future nanomedicine for photodynamic cancer therapy and imaging in cancers of the esophagus, breast, lung, colon, rectum, urinary bladder and cervix.