2009 H1N1 Influenza in Hospitalized Transplant Recipients
2009 H1N1 Influenza in Hospitalized Transplant Recipients
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DOI：
10.1097/tp.0b013e3181e86af0
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发表时间：
2010-09-15
期刊：
影响因子：
6.2
通讯作者：
Kusne, Shimon
中科院分区：
文献类型：
--
作者：
Seville, Maria Teresa A.;Blair, Janis E.;Kusne, Shimon
背景2009年H1N1流感病毒于2009年4月首次被发现，并迅速演变为大流行。移植受者中2009年H1N1流感的报告有限。我们报告我们的经验与2009年H1N1流感病毒住院移植受者。对2009年H1N1流感住院病例的持续审查确定了6名接受移植的患者。从病历中提取临床特征和结局。2009年4月27日至11月30日间，马约诊所医院收治了29名甲型流感病毒患者。29名患者中有6人是移植受者; 4人被证实感染了2009年H1N1流感病毒。大多数患者表现为急性发热性呼吸道疾病。抗病毒治疗的持续时间为5至7天，但1例患者治疗11天直至停止治疗。除1例难治性多发性骨髓瘤患者死于该病外，其余患者均迅速恢复。2009年H1N1流感在这组住院移植受者中相对较轻。大多数患者迅速改善，未观察到病毒脱落延长。
Background. The 2009 H1N1 influenza virus was first identified in April 2009 and rapidly evolved into a pandemic. There are limited reports of 2009 H1N1 influenza in transplant recipients. We report on our experience with hospitalized transplant recipients with 2009 H1N1 influenza virus.Methods. Ongoing review of hospitalized 2009 H1N1 influenza cases identified six patients who had received transplants. Clinical characteristics and outcomes were abstracted from the medical record.Results. Between April 27 and November 30, 2009, 29 patients with influenza A virus were admitted to the Mayo Clinic Hospital. Six of the 29 patients were transplant recipients; 4 were confirmed to have 2009 H1N1 influenza virus. Most patients presented with an acute febrile respiratory illness. Duration of antiviral treatment was 5 to 7 days except for one patient who was treated for 11 days until withdrawal of care. Prolonged viral shedding was not noted, and the patients recovered promptly except for a patient with recalcitrant multiple myeloma who died because of the disease.Conclusion. 2009 H1N1 influenza disease in this cohort of hospitalized transplant recipients was relatively mild. The majority of the patients improved promptly, and prolonged viral shedding was not noted.