Pediatric patients with eosinophilic esophagitis: An 8-year follow-up
Pediatric patients with eosinophilic esophagitis: An 8-year follow-up
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DOI：
10.1016/j.jaci.2006.10.044
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发表时间：
2007-03-01
影响因子：
14.2
通讯作者：
Rothenberg, Marc E.
中科院分区：
文献类型：
--
作者：
Assa'ad, Amal H.;Putnam, Philip E.;Rothenberg, Marc E.
背景：嗜酸性粒细胞性食管炎（EE）是一种胃肠道疾病，越来越多的儿童患者被诊断出来。目的：我们旨在确定儿童情感表达患者的人口统计学和特应性特征，胃肠道各节段的组织病理学，以及治疗干预对自然史的影响。方法：我们对儿童情感表达患者的数据库进行了回顾性分析，随访时间超过8年。结果：89例小儿EE患者中，男性（78.6%）、白人（94.4%）、诊断时年龄小、平均SD +/- SD、6.2 +/- 4.8岁、对环境和食物过敏原致敏的特应性反应发生率分别为79%和75%。患者食管近端和远端有EE， 77%的患者在胃、十二指肠和结肠中还存在粘膜嗜酸性粒细胞或非嗜酸性粒细胞组织病理学。EE是慢性的，平均SD持续时间为0.91 +/- 0.84年，直到第一次消退，并且是复发的；在66%的缓解患者中，79%的患者后来复发。结论：儿童嗜酸性粒细胞性食管炎是一种慢性和复发性疾病，与特应性相关，有时在胃肠道部分（而非食道）伴有随后的组织病理学。
Background: Eosinophilic esophagitis (EE) is a gastrointestinal disorder that is increasingly diagnosed in pediatric patients.Objective: We aimed to define, in pediatric patients with EE, their demographic and atopic characteristics, the histopathology of all segments of the gastrointestinal tract, and the effect of therapeutic interventions on the natural history.Methods: We conducted a retrospective analysis of a database of pediatric patients with EE followed over a period of 8 years.Results: In 89 pediatric patients with EE, male sex (78.6%), white race (94.4%), young age at diagnosis, mean +/- SD, 6.2 +/- 4.8 years, and atopy with sensitization to environmental and food allergens in 79% and 75%, respectively, were prevalent. Patients had EE of the proximal and distal esophagus, and 77% had in addition either mucosal eosinophilia or noneosinophilic histopathology in the stomach, duodenum, and colon. EE was chronic, with a duration of mean SD, 0.91 +/- 0.84 years, until first resolution, and was recurrent; of 66% of the patients who had resolution, 79% later relapsed.Conclusion: Eosinophilic esophagitis in the pediatric population is a chronic and relapsing condition, associated with atopy and sometimes with subsequent histopathology in segments of the gastrointestinal tract other than the esophagus.