The roles of microRNAs on tuberculosis infection: meaning or myth?
The roles of microRNAs on tuberculosis infection: meaning or myth?
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DOI：
10.1016/j.tube.2013.08.004
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发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Cirillo DM
中科院分区：
文献类型：
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作者：
Harapan H;Fitra F;Ichsan I;Mulyadi M;Miotto P;Hasan NA;Calado M;Cirillo DM
抗结核的中心蛋白是干扰素-γ、肿瘤坏死因子-α、白细胞介素（IL）-6和IL-1β，而IL-10主要抑制抗分枝杆菌应答。几项研究发现，在活动性和潜伏性结核病以及结核病和健康对照的巨噬细胞和自然杀伤（NK）细胞中，参与抗分枝杆菌反应的基因表达谱发生了变化。这种细胞组成的改变可能受到microRNA（miRNAs）的调控。尽管在哺乳动物细胞中只有1%的基因组转录本编码miRNA，但据预测，它们控制着60%以上的蛋白质编码基因的活性，对某些疾病的发病机理、诊断和治疗方法有着巨大的影响。已经发现几种miRNA调节T细胞分化和功能，并且在调节巨噬细胞、树突状细胞和NK细胞的先天功能中具有关键作用。本文综述了miRNAs在结核病感染中的作用，特别是其在结核病免疫学分子病理学中的新作用以及作为未来结核病诊断新靶点的研究进展。
The central proteins for protection against tuberculosis are attributed to interferon-γ, tumor necrosis factor-α, interleukin (IL)-6 and IL-1β, while IL-10 primarily suppresses anti-mycobacterial responses. Several studies found alteration of expression profile of genes involved in anti-mycobacterial responses in macrophages and natural killer (NK) cells from active and latent tuberculosis and from tuberculosis and healthy controls. This alteration of cellular composition might be regulated by microRNAs (miRNAs). Albeit only 1% of the genomic transcripts in mammalian cells encode miRNA, they are predicted to control the activity of more than 60% of all protein-coding genes and they have a huge influence in pathogenesis theory, diagnosis and treatment approach to some diseases. Several miRNAs have been found to regulate T cell differentiation and function and have critical role in regulating the innate function of macrophages, dendritic cells and NK cells. Here, we have reviewed the role of miRNAs implicated in tuberculosis infection, especially related to their new roles in the molecular pathology of tuberculosis immunology and as new targets for future tuberculosis diagnostics.