Catalytic asymmetric Darzens condensation under phase-transfer-catalyzed conditions
Catalytic asymmetric Darzens condensation under phase-transfer-catalyzed conditions
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DOI：
10.1016/s0040-4039(98)00081-1
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发表时间：
1998-04-09
影响因子：
1.8
通讯作者：
Shioiri, T
中科院分区：
文献类型：
--
作者：
Arai, S;Shioiri, T
描述了由辛可宁衍生的季铵盐（PTC A）作为相转移催化剂促进的催化不对称 Darzens 缩合。在温和的反应条件下用各种醛处理苯甲酰氯，以良好的产率和良好至中等的对映体过量得到相应的所需产物。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
The catalytic asymmetric Darzens condensation promoted by the quaternary ammonium salt (PTC A) derived from cinchonine as a phase-transfer catalyst is described. Treatment of phenacyl chloride with various aldehydes under mild reaction conditions afforded the corresponding desired product in good yield with good to moderate enantiomeric excess. (C) 1998 Elsevier Science Ltd. All rights reserved.