Body mass index and Barrett's oesophagus in women.
Body mass index and Barrett's oesophagus in women.
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DOI：
10.1136/gut.2008.174508
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发表时间：
2009-11
期刊：
影响因子：
24.5
通讯作者：
Fuchs CS
中科院分区：
文献类型：
--
作者：
Jacobson BC;Chan AT;Giovannucci EL;Fuchs CS
体重过多与胃食管反流病的症状有关，横断面研究表明体重指数（BMI）与巴雷特食管之间存在关联。我们试图前瞻性地研究BMI和其他拟人化指标对女性巴雷特食道风险的影响。前瞻性队列研究。护士健康研究：15,861名没有癌症病史的妇女，在1986年至2004年期间因任何原因接受了上消化道内窥镜检查。病理证实食管（巴雷特食管）内特化肠化生261例。自我报告的体重数据来自两年一次的问卷调查。自报身高于1976年收集，自报腰围和臀围于1986年收集。与BMI为20 - 24.9 kg/m2的女性相比，BMI为25-29.9的女性Barrett食管的多因素优势比为0.92 (95% CI 0.66-1.27)， BMI为bbb30的女性的多因素优势比为1.52 (95% CI 1.02-2.28), BMI <20的女性的多因素优势比为0.92 （95% CI 0.65-1.31）。在控制胃食管反流症状时，在整个护士健康研究队列（n=93,609）中，无论是否有内窥镜检查史，结果都是相似的。相比之下，腰臀比、腰围和身高似乎与巴雷特食管无关。肥胖但不超重的女性患巴雷特食道的风险似乎更高。
Excess body mass is associated with symptoms of gastroesophageal reflux disease, and cross-sectional studies suggest an association between body mass index (BMI) and Barrett’s oesophagus. We sought to prospectively examine the influence of BMI and other anthropomorphic measures on the risk for Barrett’s oesophagus among women. Prospective cohort study. Nurses’ Health Study. 15,861 women without a history of cancer, who underwent upper gastrointestinal endoscopy for any reason between 1986 and 2004. 261 cases of pathologically confirmed specialised intestinal metaplasia within the oesophagus (Barrett’s oesophagus). Self-reported data on weight were collected from biennial questionnaires. Self-reported height was collected in 1976, and self-reported waist and hip circumferences were collected in 1986. Compared to women with BMI 20–24.9 kg/m2, women with BMI 25–29.9 had a multivariate odds ratio for Barrett’s oesophagus of 0.92 (95% CI 0.66–1.27), women with BMI >30 had a multivariate odds ratio of 1.52 (95% CI 1.02–2.28), and women with BMI <20 had a multivariate odds ratio of 0.92 (95% CI 0.65–1.31). Results were similar when controlling for symptoms of gastroesophageal reflux, and among the entire Nurses’ Health Study cohort (n=93,609) regardless of a history of endoscopy. In contrast, waist-to-hip ratio, waist circumference, and height did not appear to be associated with Barrett’s oesophagus. Obese, but not overweight, women appear to be at increased risk for Barrett’s oesophagus.
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影响因子：
9.8
作者：
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通讯作者：
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