Breast cancer chemotherapy-related cognitive dysfunction.
Breast cancer chemotherapy-related cognitive dysfunction.
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DOI：
10.3816/cbc.2002.s.018
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发表时间：
2002-12-01
影响因子：
3.1
通讯作者：
Saykin, Andrew J
中科院分区：
文献类型：
--
作者：
Ahles, Tim A;Saykin, Andrew J
全身化疗的认知副作用已经成为乳腺癌幸存者、她们的家人和卫生保健专业人员日益关注的问题。越来越多的研究支持这样一种假设，即化疗至少可以在一部分癌症幸存者中产生长期的认知变化。我们回顾了表明全身化疗是认知改变的原因的证据；描述由于缺乏纵向研究和知识空白而造成的局限性（即，没有明确的机制表明化疗可以产生认知变化）；讨论可能增加化疗引起的认知变化风险的因素，如年龄、智商/教育程度、心理、遗传和激素因素；并概述未来的研究方向。未来的研究包括对预处理神经心理学评估进行大规模的纵向研究，使用成像技术和开发动物模型来研究化疗引起的认知功能改变的机制，以及开发干预措施来预防或减少化疗的负面认知影响
Cognitive side effects of systemic chemotherapy have become an increasing concern among breast cancer survivors, their families, and health care professionals. A growing body of research supports the hypothesis that chemotherapy can produce long-term cognitive changes in at least a subgroup of cancer survivors. We review evidence implicating systemic chemotherapy as the cause of cognitive changes; describe the limitations due to lack of longitudinal studies and gaps in knowledge (ie, no clear mechanism by which chemotherapy can produce cognitive changes has been proposed); discuss possible factors like age, intelligence quotient/education, and psychological, genetic, and hormonal factors that might increase risk for chemotherapy-induced cognitive changes; and outline future directions for research. Such future research includes large-scale, longitudinal studies of pretreatment neuropsychological assessments, use of imaging techniques and the development of animal models to study the mechanisms of chemotherapy-induced changes in cognitive functioning, and the development of interventions to prevent or reduce the negative cognitive effects of chemotherapy