Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections
Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections
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DOI：
10.1100/2011/212680
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发表时间：
2011-01-01
影响因子：
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通讯作者：
Re, Fabio
中科院分区：
文献类型：
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作者：
Sahoo, Manoranjan;Ceballos-Olvera, Ivonne;Re, Fabio
炎性小体是一种重要的先天免疫途径，它调节至少两种保护宿主免受感染的反应：(1)促炎细胞因子IL-1 β和IL-18的分泌；(2)诱导焦亡（一种细胞死亡形式）。炎性小体是一种多蛋白复合物，含有nod样受体家族或PYHIN家族的模式识别受体和蛋白酶caspase-1，已鉴定出不同类型。各种病原体激活不同炎症小体的分子方面正在迅速阐明，它们在感染过程中的作用正在被表征。IL-1 β和IL-18的产生和被感染细胞的诱导热亡已被证明对许多感染因子具有保护作用。在这里，我们回顾了最近关于细菌感染背景下炎性体激活的文献，并确定了未来需要回答的重要问题。
The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1 beta and IL-18 and (2) induction of pyroptosis, a form of cell death. Inflammasomes, of which different types have been identified, are multiprotein complexes containing pattern recognition receptors belonging to the Nod-like receptor family or the PYHIN family and the protease caspase-1. The molecular aspects involved in the activation of different inflammasomes by various pathogens are being rapidly elucidated, and their role during infections is being characterized. Production of IL-1 beta and IL-18 and induction of pyroptosis of the infected cell have been shown to be protective against many infectious agents. Here, we review the recent literature concerning inflammasome activation in the context of bacterial infections and identify important questions to be answered in the future.