Diagnostic assays for chronic granulomatous disease and other neutrophil disorders.
Diagnostic assays for chronic granulomatous disease and other neutrophil disorders.
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慢性肉芽肿病和其他中性粒细胞疾病的诊断测定。
DOI：
10.1007/978-1-62703-845-4_31
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Holland,StevenM
中科院分区：
文献类型：
--
作者：
Elloumi,HoudaZghal;Holland,StevenM
由于中性粒细胞是抵御细菌和真菌感染的主要细胞防御系统，影响这些白细胞的疾病通常会使个人容易受到严重和反复的感染。因此，对这类疾病的诊断是指导患者长期治疗/护理的重要第一步。在此，我们描述了识别慢性肉芽肿性疾病、白细胞黏附缺陷和中性粒细胞减少的方法。这些分析相对简单，成本效益高，可以用大多数实验室现有的设备进行。
Inasmuch as neutrophils are the primary cellular defense against bacterial and fungal infections, disorders that affect these white cells typically predispose individuals to severe and recurrent infections. Therefore, diagnosis of such disorders is an important first step in directing long-term treatment/care for the patient. Herein, we describe methods to identify chronic granulomatous disease, leukocyte adhesion deficiency, and neutropenia. The assays are relatively simple to perform and cost effective and can be performed with equipment available in most laboratories.