Peripheral CD4+T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion
Peripheral CD4+T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion
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DOI：
10.1007/s10165-007-0010-3
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发表时间：
2008-02-01
影响因子：
2.2
通讯作者：
Nakamura, Seiji
中科院分区：
文献类型：
--
作者：
Miyake, Katsuhisa;Moriyama, Masafumi;Nakamura, Seiji
Mikulicz病（MD）是一种独特的IgG 4相关的全身性疾病，表现为泪腺和唾液腺增大，与干燥综合征有很大不同。一名男性患者，胸腔积液，颌下腺肿胀，主动脉旁、纵隔和肾旁淋巴结肿胀，诊断为MD。对患者外周血CD 4 + T细胞的分析显示Th 1/Th 2平衡向Th 2偏移。泼尼松龙治疗可改善病情，纠正Th 1/Th 2失衡。
Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjogren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.