Characterization of the effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in Brown Norway and Wistar-Kyoto rats
Characterization of the effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in Brown Norway and Wistar-Kyoto rats
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DOI：
10.1016/j.ejphar.2004.11.055
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发表时间：
2005-01-10
影响因子：
5
通讯作者：
Conti, LH
中科院分区：
文献类型：
--
作者：
Conti, LH
感觉-运动门控，如通过惊吓反应的前脉冲抑制所评估的，在失眠患者中减少。我们以前已经表明，近交系布朗挪威（BN）大鼠表现出显着较少的声惊吓反应的前脉冲抑制比近交系Wistar-Kyoto（WKY）大鼠，和前脉冲抑制减少了中央管理的神经肽，促肾上腺皮质激素释放因子（CRF）在两个菌株。本研究旨在确定CRF外周给药是否会改变前脉冲抑制，降低前脉冲抑制的低阈值剂量在两种大鼠品系中是否相同。以及CRF受体拮抗剂的中枢给药是否增强BN株中的前脉冲抑制。CRF诱导的行为激活也进行了检查，以确定是否两种大鼠品系的CRF，不涉及惊吓反应的行为效应的敏感性差异。在每个实验中，BN大鼠表现出显着低于WKY大鼠的前脉冲抑制。皮下注射CRF对两种大鼠品系的惊吓幅度或惊吓反应的前脉冲抑制均没有影响。在BN，但不是在WKY大鼠，低剂量CRF（0.3微克）减少前脉冲抑制。然而，CRF剂量不改变WKY菌株的前脉冲抑制。确实导致了行为激活所测试的CRF剂量不影响基线惊吓幅度。CRF受体拮抗剂的中枢给药。在两种大鼠品系中，astressin对前脉冲抑制或惊吓幅度没有影响。CRF受体拮抗剂的中枢给药。D-Phe CRF（12-41）对WKY大鼠的前脉冲抑制作用无影响，仅引起少量的前脉冲抑制。BN大鼠的前脉冲抑制无显著增加。而降低惊吓幅度。结果表明，CRF减少声惊吓反应的前脉冲抑制独立的垂体-肾上腺轴上的影响，内源性CRF有最多，在BN大鼠中发现的低前脉冲抑制的一个小的作用。(C)2004 Elsevier B.V保留所有权利。
Sensori-motor gating, as assessed by prepulse inhibition of the startle response is diminished in patients with schizophternia. We have previously shown that inbred Brown Norway (BN) rats display significantly less prepulse inhibition of the acoustic startle response than inbred Wistar-Kyoto (WKY) rats, and that prepulse inhibition is decreased by central administration of the neuropeptide, corticotropin-releasing factor (CRF) in both strains. The present study was conducted to establish whether peripheral administration of CRF alters, prepulse inhibition, whether a low, threshold dose for decreasing prepulse inhibition is the same in the two rat strains. and whether central administration of a CRF receptor antagonist enhances prepulse inhibition in the BN strain. CRF-induced behavioral activation was also examined to determine whether the two rat strains are differentially sensitive to a behavioral effect of CRF that does not involve the startle response. In each experiment, BN rats showed significantly less prepulse inhibition than WKY rats. Subcutaneous administration of CRF had no affect on startle amplitude or prepulse inhibition of the startle response in either rat strain. In BN but not in WKY rats, low-dose CRF (0.3 mug) decreased prepulse inhibition. However, doses of CRF that did not alter prepulse inhibition in the WKY strain. did result in behavioral activation. No dose of CRF tested affected baseline startle amplitude. Central administration of the CRF receptor antagonist. astressin had no effect on prepulse inhibition or startle amplitude in either rat strain. Central administration of the CRF receptor antagonist. D-Phe CRF (12-41) had no effect on prepulse inhibition in WKY rats, resulted in a only a small. non-significant increase in prepulse inhibition in BN rats. while it decreased startle amplitude. The results suggest that CRF reduces prepulse inhibition of the acoustic startle response independently of effects on the pituitary-adrenal axis, and that endogenous CRF has at most, a minor role in the low prepulse inhibition found in BN rats. (C) 2004 Elsevier B.V All rights reserved.