Rate of disappearance of diphtheria toxoid injected into rabbits and guinea-pigs: Toxoid precipitated wtth alum.
Rate of disappearance of diphtheria toxoid injected into rabbits and guinea-pigs: Toxoid precipitated wtth alum.
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DOI：
10.1002/path.1700340214
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发表时间：
1931-01-01
期刊：
影响因子：
--
通讯作者：
Stevens, MF
中科院分区：
文献类型：
--
作者：
Glenny, AT;Buttle, GAH;Stevens, MF
用三种方法研究了注射类毒素后的消除率：（1）在注射类毒素后的不同时间间隔注射抗毒素阻断豚鼠的免疫力;（2）在注射后测定家兔血液中的类毒素;（3）在注射类毒素后注射中和剂量的抗毒素，并估计血液中过量的抗毒素。所有3种方法均显示类毒素被非常迅速地消除或破坏，在24小时结束时仅剩余约10-30%。明矾沉淀的类毒素部分保留在注射部位附近，因此比普通类毒素起更长时间的刺激作用，因此其抗原效率增加。其它沉淀剂，例如，Ce（NO3）3、ZnS 〇 4和CaCl 2以类似的方式起作用。
The rate of elimination of toxoid injected into animals was studied by 3 methods: (1) Blocking of immunity in guinea pigs injected with toxoid by injecting antitoxin at various intervals afterwards; (2) measuring the toxoid in the blood of rabbits after an injection; (3) injecting a neutralizing dose of antitoxin after the toxoid, and estimating the excess antitoxin in the blood. All 3 methods show that toxoid is eliminated or destroyed very rapidly, some 10-30% only remaining at the end of 24 hrs. Toxoid precipitated by alum is retained, in part, near the site of injection and therefore acts as a more prolonged stimulus than plain toxoid, hence its increased antigenic efficiency. Other precipitating agents, e.g., Ce(NO3)3, ZnS04 and CaCl2, act in a similar manner.