Hormonal changes during menopause
Hormonal changes during menopause
复制标题
DOI：
10.1016/j.maturitas.2009.03.009
复制
发表时间：
2009-06-20
期刊：
影响因子：
4.9
通讯作者：
Palacios, Santiago
中科院分区：
文献类型：
--
作者：
Al-Azzawi, Farook;Palacios, Santiago
卵巢衰老在生命的第四和第五个十年逐渐发生，导致平均年龄约51岁的更年期。这种衰老导致激素环境的变化，雌激素和雄激素水平下降。手术绝经（双侧卵巢切除术）或癌症治疗导致的卵巢功能衰竭也可能引起类似的变化。雌激素和雄激素水平的下降会影响身体的许多组织，并会产生各种体征和症状，包括血管炎症状，骨密度降低，情绪和能量变化，阴毛脱落和生殖器组织变化，以及对性功能的影响。准确测量绝经后妇女的睾酮水平需要在该人群中观察到的睾酮水平较低范围内验证的方法。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Ovarian senescence occurs gradually during the fourth and fifth decades of life, leading to menopause at an average age of about 51 years. This senescence results in a changing hormonal milieu, with decreases in the levels of estrogens and androgens. Similar changes may be induced by surgical menopause (bilateral oophorectomy) or ovarian failure resulting from cancer treatment. The declining levels of estrogens and androgens affect many tissues of the body and can produce a variety of signs and symptoms, including vasomotor symptoms, decreased bone density, changes in mood and energy, loss of pubic hair and changes in the genital tissues, and effects on sexual function. Accurate measurement of testosterone levels in postmenopausal women requires methods that are validated in the lower ranges of testosterone level observed in this population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.