Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device.
Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device.
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DOI：
10.2147/opth.s104721
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tsunoda K
中科院分区：
文献类型：
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作者：
Nakamura N;Fujinami K;Mizuno Y;Noda T;Tsunoda K
全场视网膜电信号(ERG)用于评估各种遗传性和获得性视网膜疾病患者的视网膜功能。然而，ERG记录需要相对侵入性的程序，包括散瞳和使用隐形眼镜电极。因此，拥有一种更简单、无创的筛查方法将是有帮助的。这项研究的目的是确定一种新的、手持的、便携式的视网膜电图设备RETERVAL™是否可以用于筛查锥体功能障碍患者。对35例(35只眼)使用隐形眼镜电极的常规ERG系统检查出的视锥反应减弱的患者进行了研究。病因包括色盲、视锥细胞营养不良、视锥视杆细胞营养不良、视网膜色素变性、脉络膜营养不良、自身免疫性视网膜病变和Stargardt病。使用RETERVAL™记录闪光ERG，记录条件为皮肤电极(刺激强度3.0cd·S/m2；频率28.3 Hz)，并与50只健康眼的反应进行比较。分析3个年龄组：A组，≤20岁；B组，21~40岁；C组，≥41岁，闪光ERG的基本成分的波幅和潜伏期。在所有年龄组中，视锥细胞功能障碍患者的ERG波幅明显小于对照组，潜伏期显著长于对照眼。除1例患者外，其余患者的闪光幅度均低于对照眼的平均−2.0标准差。RETERVAL™有可能被用于筛查锥体功能障碍。整个检查耗时5分钟，不需要放大瞳孔或隐形眼镜电极。虽然闪烁反应不能提供有关暗视功能的信息，但RETevalERGERG设备可以用来确定哪些患者需要在暗视和明视条件下对散瞳进行额外的全场™测试。
Full-field electroretinograms (ERGs) are used to evaluate retinal function in patients with various types of hereditary and acquired retinal diseases. However, ERG recordings require relatively invasive procedures, including pupillary dilation and the use of contact lens electrodes. Thus, it would be helpful to have a simpler and noninvasive screening method. The purpose of this study was to determine whether a new, handheld, portable ERG device, RETeval™, can be used to screen patients for cone dysfunction. Thirty-five eyes of 35 patients who had reduced cone responses ascertained by a conventional ERG system using contact lens electrodes were studied. The causative diseases included achromatopsia, cone dystrophy, cone-rod dystrophy, retinitis pigmentosa, choroidal dystrophy, autoimmune retinopathy, and Stargardt disease. The flicker ERGs were recorded with the RETeval™ under undilated conditions with skin electrodes (stimulus strength, 3.0 cd·s/m2; frequency, 28.3 Hz), and the responses were compared to that of 50 healthy eyes. The amplitudes and implicit times of the fundamental component of the flicker ERGs were analyzed in three age groups: Group A, ≤20 years; Group B, 21–40 years; and Group C, ≥41 years. In all of the age groups, the amplitudes of the ERGs were significantly smaller and the implicit times significantly longer in patients with cone dysfunction than in the control eyes. All but one of the patients had flicker amplitudes lower than the mean −2.0 standard deviation of control eyes. The RETeval™ has a potential of being used to screen for cone dysfunction. The entire examination takes <5 minutes and does not require pupil dilatation or a contact lens electrode. Although the flicker responses do not provide information on the scotopic functions, the RETeval™ device can be used to determine which patients require additional full-field ERG testing with dilated pupils under both scotopic and photopic conditions.