Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors
Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors
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DOI：
10.1007/s002840010315
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发表时间：
2001-11-01
影响因子：
2.6
通讯作者：
Salminen, S
中科院分区：
文献类型：
--
作者：
He, F;Ouwehand, AC;Salminen, S
从健康成人（30-40岁）和老年人（70岁以上）的粪便中分离到51株双歧杆菌。B。你好，B。breve，B.和B。从健康成人和B.我和B。从老年受试者中提取。测试的细菌在体外以菌株依赖性方式与肠粘液结合。这些菌株分离自健康成人，尤其是B。比从老年人中分离出来的更好地与肠粘液结合。这些结果表明，人双歧杆菌植物群的粘膜粘附特性随着宿主的老化而降低。这种向粘附能力降低的双歧杆菌植物群的转变可以解释老年人肠道微植物群中双歧杆菌水平的降低。
Fifty-one Bifidobacterium strains were isolated from the feces of healthy adults (30-40 years old) and seniors (older than 70 years of age). B. adolescentis, B. breve, B. infantis, and B. longum were isolated from the healthy adults and B. adolescentis and B. longum from elderly subjects. The tested bacteria bound, in vitro, to intestinal mucus in a strain dependent manner. The strains isolated from healthy adults, and especially B. adolescentis, bound better to intestinal mucus than those isolated from seniors. These results indicate that the mucosal adhesive properties of the human Bifidobacterium flora were reduced with the aging of the host. This shift to a Bifidobacterium flora with reduced adhesive abilities may explain the decrease in bifidobacteria levels in the intestinal microflora of aging people.