Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnant Women and Their Infants.
Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnant Women and Their Infants.
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严重急性呼吸系统综合症冠状病毒 2 感染对孕妇及其婴儿的影响。
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Guoping Xiong
中科院分区：
文献类型：
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作者：
Hui Yang;Bin Hu;Sudong Zhan;Li-Ye Yang;Guoping Xiong
背景。一种新型冠状病毒的大流行，称为严重急性呼吸综合征冠状病毒2（SARSCoV-2），已经造成了前所未有的全球健康负担。目标。-研究SARS-CoV-2感染对孕产妇、胎儿和新生儿发病率及其他不良产科结局的影响。设计。-包括2020年1月20日至3月19日在武汉one.center上收治的所有2019年冠状病毒病（COVID-19）孕妇疑似病例。回顾性收集并分析了COVID-19妊娠的详细临床数据。结果。-对27例实验室或临床确诊为SARS-CoV-2感染的孕妇（包括4例早期妊娠）和23例晚期妊娠妇女所生的24例新生儿进行了分析。入院时，46.2%（13/27）的患者出现症状，包括发热（11/27）、咳嗽（9/27）和呕吐（1/27）。在81.5%（22/27）的患者中观察到总淋巴细胞计数降低。26例患者胸部计算机断层扫描显示典型的病毒性肺炎，而1例确诊为COVID-19感染的患者胸部计算机断层扫描显示无异常。一位母亲在分娩后3.5天出现严重肺炎。无产妇或围产期死亡。发生。此外，1例早期早产新生儿的母亲有胎膜早破并发症，高度怀疑有SARS-CoV-2感染，经重复实时逆转录聚合酶链反应检测SARS-CoV-2阴性。观察到妊娠早期和晚期感染COVID-19的女性在淋巴细胞减少症和血小板减少症的发生率方面存在统计学差异。结论。-无严重并发症报告。在研究队列中，观察到1例严重病例和1例围产期感染。应尽最大努力减少COVID-19感染对妊娠的致病影响。
Context.—The pandemic of a novel coronavirus, termed.severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), has created an unprecedented global health.burden..Objective.—To investigate the effect of the SARS-CoV-2.infection on maternal, fetal, and neonatal morbidity and.other poor obstetrical outcomes..Design.—All suspected cases of pregnant women with.coronavirus disease 2019 (COVID-19) admitted into one.center in Wuhan from January 20 to March 19, 2020, were.included. Detailed clinical data of those pregnancies with.COVID-19 were retrospectively collected and analyzed..Results.—Twenty-seven pregnant women (4 early pregnancies included) with laboratory or clinically confirmed.SARS-CoV-2 infection and 24 neonates born to the 23.women in late pregnancy were analyzed. On admission,.46.2% (13 of 27) of the patients had symptoms, including.fever (11 of 27), cough (9 of 27), and vomiting (1 of 27)..Decreased total lymphocytes count was observed in.81.5% (22 of 27) of patients. Twenty-six patients showed.typical viral pneumonia by chest computed tomography.scan, whereas 1 patient confirmed with COVID-19.infection showed no abnormality on chest computed.tomography. One mother developed severe pneumonia 3.days after her delivery. No maternal or perinatal death.occurred. Moreover, 1 early preterm newborn born to a.mother with the complication of premature rupture of fetal.membranes, highly suspected to have SARS-CoV-2 infection, was SARS-CoV-2 negative after repeated real-time.reverse transcriptase polymerase chain reaction testing..Statistical differences were observed between the groups.of women in early and late pregnancy with COVID-19 in.the occurrence of lymphopenia and thrombocytopenia..Conclusions.—No major complications were reported.among the studied cohort, though 1 serious case and 1.perinatal infection were observed. Much effort should be.made to reduce the pathogenic effect of COVID-19.infection in pregnancies.