IN-VIVO VOLTAMMETRIC MEASUREMENT OF EVOKED EXTRACELLULAR DOPAMINE IN THE RAT BASOLATERAL AMYGDALOID NUCLEUS
IN-VIVO VOLTAMMETRIC MEASUREMENT OF EVOKED EXTRACELLULAR DOPAMINE IN THE RAT BASOLATERAL AMYGDALOID NUCLEUS
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DOI：
10.1113/jphysiol.1994.sp020246
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发表时间：
1994-07-15
影响因子：
5.5
通讯作者：
WIGHTMAN, RM
中科院分区：
文献类型：
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作者：
GARRIS, PA;WIGHTMAN, RM
1. 使用碳纤维微电极上的快速扫描循环伏安法建立了基底外侧杏仁核（BAN）中诱发的细胞外多巴胺的体内测量。2． BAN 中诱发的细胞外多巴胺的鉴定是基于解剖学、电化学和药理学标准。电化学和药理学证据表明该物质是儿茶酚胺。引发溢出的中脑位点和支持溢出的杏仁核位点与中杏仁核多巴胺神经支配密切相关。3．在 BAN、尾壳核和杏仁核-纹状体过渡区观察到诱发多巴胺溢出的动态和幅度存在显着差异。结果强调了对杏仁核中细胞外多巴胺进行空间分辨测量的重要性。4。中杏仁核多巴胺神经元与中纹状体多巴胺神经元具有相似的释放特征，但与中前额皮质多巴胺神经元共享使用更大比例的神经元内多巴胺储存进行释放的能力。
1. The in vivo measurement of evoked extracellular dopamine was established in the basolateral amygdaloid nucleus (BAN) using fast-scan cyclic voltammetry at carbon-fibre microelectrodes.2. The identification of evoked extracellular dopamine in the BAN was based on anatomical, electrochemical and pharmacological criteria. Electrochemical and pharmacological evidence indicated that the species was a catecholamine. Mesencephalic sites eliciting overflow and amygdaloid sites supporting overflow correlated well with the mesoamygdaloid dopamine innervation.3. Marked differences in the dynamics and magnitude of evoked dopamine overflow were observed in the BAN, caudate-putamen and amygdalo-striatal transition area. The results underscore the importance of making spatially resolved measurements of extracellular dopamine in the amygdala.4. Mesoamygdaloid dopamine neurons have similar release characteristics as mesostriatal dopamine neurons but share with mesoprefrontal cortical dopamine neurons the ability to use a greater percentage of intraneuronal dopamine stores for release.