Treatment of idiopathic intracranial hypertension:: topiramate vs acetazolamide, an open-label study
Treatment of idiopathic intracranial hypertension:: topiramate vs acetazolamide, an open-label study
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DOI：
10.1111/j.1600-0404.2007.00905.x
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发表时间：
2007-11-01
影响因子：
3.5
通讯作者：
Akyuerekli, Oe.
中科院分区：
文献类型：
--
作者：
Celebisoy, N.;Goekcay, F.;Akyuerekli, Oe.
Objectives - To assess the efficacy of topiramate in treatment of idiopathic intracranial hypertension（IIH）and to comparison it with acetazolamide.Methods -40 patients diagnosed as IIH and randomly assigned to treatment with either acetazolamide or topiramate were prospectively assessed.在第三，第六和第十二个月结束时的视野改善被考虑到considering.Results -人口统计学，临床特征和两个治疗组的脑脊液（CSF）压力是相似的，在开始的研究。当将每组的随访视野等级与研究开始时的视野等级进行比较时，检测到两种药物的统计学显著改善。当两个治疗组的结果相互比较时，不存在统计学显著差异。托吡酯组的体重明显减轻。结论托吡酯似乎是有效的治疗IIH。体重减轻以及CSF形成减少是可能的作用机制。
Objectives - To assess the efficacy of topiramate in the treatment of idiopathic intracranial hypertension (IIH) and to compare it with acetazolamide.Methods - Fourty patients diagnosed as IIH and randomly assigned to treatment with either acetazolamide or topiramate were assessed prospectively. Improvement in the visual fields at the end of third, sixth and twelfth months were taken into consideration.Results - The demographic, clinical features and the cerebrospinal fluid (CSF) pressure of the two treatment groups were similar at the beginning of the study. When the follow-up visual field grades were compared with the visual field grades at the beginning of the study in each group a statistically significant improvement was detected with both drugs. When the results of the two treatment groups were compared with each other no statistically significant difference was present. Prominent weight loss was recorded in the topiramate group.Conclusions - Topiramate seems to be effective in the treatment of IIH. Weight reduction as well as the reduction of the CSF formation is the possible mechanism of action.