Synthesis of CF3-containing oxazolines via trifluoromethylation of allylamides with Togni reagent in the presence of alkali metal iodides
Synthesis of CF3-containing oxazolines via trifluoromethylation of allylamides with Togni reagent in the presence of alkali metal iodides
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DOI：
10.1016/j.jfluchem.2017.07.012
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发表时间：
2017-11
影响因子：
1.9
通讯作者：
S. Kawamura;Daisuke Sekine;M. Sodeoka
中科院分区：
文献类型：
--
作者：
S. Kawamura;Daisuke Sekine;M. Sodeoka
本文报道了一种利用Togni试剂在碱金属碘化物存在下，烯丙酰胺三氟甲基化合成含cf3恶唑啉的高效方法，碱金属碘化物在选择性生产所需恶唑啉中起着关键作用。通常用于三氟氧基甲基化的铜催化剂不能有效地进行反应。我们的方法提供了多种含cf3的恶唑啉，它们是药物，农用化学品和功能材料的潜在候选者。
We report an efficient synthetic method for CF3-containing oxazolines via trifluoromethylation of allylamides by using Togni reagent in the presence of alkali metal iodides, which play a key role in selective production of the desired oxazoline. The reaction did not proceed efficiently with copper catalysts commonly used for oxytrifluoromethylations. Our method afforded a wide variety of CF3-containing oxazolines, which are potential candidates for pharmaceuticals, agrochemicals, and functional materials.