Motion Sickness and Resting Energy Expenditure in Chinese Male Adults.
Motion Sickness and Resting Energy Expenditure in Chinese Male Adults.
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DOI：
10.3357/amhp.4438.2016
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发表时间：
2016-04
影响因子：
0.9
通讯作者：
Junqin Wang;Ruirui Qi;Leilei Pan;W. Zhou;Li-li Zhang;Yi-ling Cai
中科院分区：
文献类型：
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作者：
Junqin Wang;Ruirui Qi;Leilei Pan;W. Zhou;Li-li Zhang;Yi-ling Cai
背景运动病可通过增强心率影响能量稳态。本研究验证了静息能量消耗（REE）作为产热的主要组成部分，可能也在运动病中发挥作用的假设。方法对71名健康男性志愿者进行了晕船对REE的影响研究。在基线、航行和恢复阶段观察REE、心率变异性（HRV）、血ghrelin水平和瘦素水平的变化。晕船的严重程度进行了评估，使用Graybiel晕动病问卷（GMSQ），恶心综合征评级（NSR）的每个参与者也进行了评估。用间接量热法测定稀土元素。心率变异性是从心电图中推导出来的，用于分析心脏交感迷走神经活动。采用放射免疫法测定血中ghrelin和leptin水平。结果航行中重度晕船者的GMSQ和NSR评分高于轻度和中度晕船者。与基线和恢复水平相比，REE显著下降，并且低于轻度和中度晕船的受试者。心脏交感神经活动明显减少，而迷走神经活动增加。血浆ghrelin水平也显著升高，并与REE水平呈负相关，与NSR和HRV LF/HF比值较基线的变化呈正相关。严重的运动病诱导REE抑制，这可能是由于人类交感迷走神经活动和血浆ghrelin水平的显着改变。
BACKGROUND Motion sickness can influence energy homeostasis by enhancing thermolysis. This study tested the hypothesis that resting energy expenditure (REE), as the major component of thermogenesis, might also play a role during motion sickness. METHODS The effect of seasickness on REE at sea was examined in 71 healthy Chinese male volunteers. Change in REE, heart rate variability (HRV), blood ghrelin levels, and leptin levels were observed across baseline, voyage, and recovery stages. Seasickness severity was assessed using the Graybiel motion sickness questionnaire (GMSQ), and the nausea syndrome rating (NSR) of each participant was also evaluated. REE was examined by indirect calorimetry. HRV was derived from the electrocardiogram to analyze cardiac sympathovagal activity. Blood ghrelin and leptin levels were tested by radioimmunoassay. RESULTS In subjects with severe seasickness during the voyage, the GMSQ and NSR scores were higher than in subjects with slight and moderate seasickness. The REE declined significantly compared to baseline and recovery levels and was lower than in subjects with slight and moderate seasickness. Cardiac sympathetic activity was significantly decreased, while vagal activity was increased. Plasma ghrelin levels were also significantly increased and were negatively correlated with the measured REE levels and positively correlated with NSR as well as change of HRV LF/HF ratio from baseline. DISCUSSION Severe motion sickness induces REE suppression, which may be attributed to dramatic alteration of sympathovagal activity and plasma ghrelin levels in humans.